A Summary of the Advances in Ophthalmic Drug Delivery via Iontophoresis and Microneedles
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 14, Issue 4
Abstract
Drug delivery to the posterior segment of the eye is a significantly challenging task due to the underlying physiological, anatomical and metabolic constraints. Delivery of drugs through ophthalmic route is significantly hindered by multiple physiological processes including potential static and dynamic barriers. Moreover, efflux pumps expressed on ocular tissues severely restrict the intra-ocular penetration of drugs, especially into the posterior ocular tissues. However, severe ocular complications which may be sight threatening, pose an urgency for the intervention/ treatment. Currently, invasive intravitreal injections are widely used to drugs/drug candidates to retina and vitreous body. Therefore, non-invasive drug delivery strategies that overcome the barriers encountered in the ocular milieu should be developed and explored. Various topical formulation approaches are being designed in order to address the safety and patient compliance issues associated with invasive routes. In this review, the targeted drug delivery to the ocular posterior segment via minimally invasive approaches is discussed.
Authors and Affiliations
Daniel Vettori
Keywords
Related Articles
- EP ID EP342243
- DOI 10.9734/BJPR/2016/30601
- Views 98
- Downloads 0
Natural Sources of Taxol
Taxol® is the most successful anticancer agent developed in the last 50 years. The alkaloid taxol and other taxoids were at first isolated from T. brevifolia. Because of the small yield that threatened existence of the n...
Tricyclic Pyrazoles: Synthesis, Characterization, Antimicrobial, Antituberculosis, and Antitumor Activity of N,1-Diphenyl-1,4-dihydrothiochro-meno[4,3-c]pyrazole-3-carboxamide-5,5-dioxide Derivatives
Aims: A series of N,1-diphenyl-1,4-dihydrothiochromeno[4,3-c]pyrazole-3-carboxamide 5,5-dioxide derivatives (6a-m) were synthesized and evaluated for anticancer, antibacterial, and antifungal activity. Methodology: React...
Antioxidant and Hepatoprotective Activity of Ethanol Extract of Valeriana wallichii in CCl4 Treated Rats
Aims: To screen the hepatoprotective and antioxidant activity of ethanol extract of roots of Valeriana wallichii DC (Valerianaceae)(VWE). Study Design: Animal study. Place and Duration of Study: Department of Pharmacolog...
Use of Xanthan Gum in the Formulation of Diethylcarbamazine for Targeted Drug Delivery
Matrix tablets were prepared using xanthan gum (XG) and Diethylcarbamazine was used as model drug. The controlled release of the drug by the polymer matrices in the upper gastrointestinal tract (GIT) was assessed through...
Evaluation of Hypolipidemic Activity of Allium schoenoprasum in Albino Rats
Aim of Study: This study was designed to evaluate the hypolipidemic action of aqueous and ethanolic extracts of leaves of Allium schoenoprasum in albino rats. Methodology: 500 g of dried leaves powder was initially soake...