A VALIDATED RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF FLUOXETINE HYDROCHLORIDE AND OLANZAPINE IN PHARMACEUTICAL DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Fluoxetine hydrochloride and Olanzapine in pharmaceutical dosage forms. The mobile phase consisted of Acetonitrile: pot.dihydrogen phosphate buffer: Triethylamine (0.2 %) (0.1% v/v ortho phosphoric acid, PH 3.1) in the ratio of 40:60:0.2 v/v/v delivered at a flow rate of 1.0 ml / min and wavelength of detection at 233 nm. The retention times of Fluoxetine and Olanzapine were 1.96 min and 5.59 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in combined dosage forms.
Authors and Affiliations
M. M. Eswarudu, M. Anitha, N. Gayathri, T. Chaithanya
Keywords
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