FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF GLICLAZIDE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 9
Abstract
Mouth dissolving tablets is the fast growing and highly accepted drug delivery system, convenience of self administration, compactness and easy manufacturing. Gliclazide is a second generation anti-diabetic drug used for the treatment of type II diabetes. The drawback of the drug is, it is practically insoluble in water and so possesses poor solubility, GI absorption and bioavailability. Hence the objective of the work is to develop mouth dissolving tablets of gliclazide by direct compression method using three super disintegrants, viz., hypromellose, crospovidone and sodium starch glycolate at different concentrations with microcrystalline cellulose. The bland were examined for angle of repose, bulk density, tapped density, compressibility index and hausner’s ratio. The prepared tablets were evaluated for thickness, hardness, friability, and weight variation, content uniformity, wetting time, water absorption ratio, in vitro dispersion time, dissolution studies and FTIR studies. Twelve formulations F1 to F12 were prepared with three super disintegrants with different concentration. The optimum formulation was chosen and their optimum results were found to be in close agreement with experimental finding. Among three super disintegrants crospovidone F6 emerged as overall best formulation. Short term stability studies on the formulations indicated no significant changes in the drug content and in vitro dispersion time.
Authors and Affiliations
Pratik Chauhan , Ramanjaneyulu Javvaji , Senthil Adimoolam , Ravikumar , Narayana Swamy
Keywords
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