A VALIDATED SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE AND LEVOCETIRIZINE DIHYDROCHLORIDE IN TABLET FORMULATIONS
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
A simple, precise and accurate spectrophotometric method was developed for simultaneous estimation of Ambroxol HCl and LevoCetirizine DiHCl in bulk and tablet dosage form. This method is based on use of Derivative method for simultaneous estimation of both the drug from tablet and Distilled water is used as solvent. Ambroxol HCl shows maximum absorption at 244nm and LevoCetirizine DiHCl shows absorption at 231 nm. Ambroxol HCL and LevoCetirizine HCl obeys Beer,s law in the concentration range 0-32 ug/ml and 0-30ug/ml respectively.During estimation of Tablet no interference was found from excipients. The dosage form contains 60 mg Ambroxol HCl and 5 mg LevoCetirizine DiHCl.The suitability of this method for estimation of both drugs was proved by validation. Statistical analysis data shows that the developed method is sound under analytical condition and can be used for routine analysis of both drugs.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP331035
- DOI -
- Views 124
- Downloads 0
DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS DETERMINATION OF PARITAPREVIR, RITONAVIR AND OMBITASVIR IN FIXED TABLET DOSAGE FORM
Developing a single analytical method for the estimation of individual drugs is very challenging, due to the formation of drug-drug and drug-excipient interactions. The present study demonstrates the applicability of the...
FORMULATION AND DEVELOPMENT OF TASTE MASKED ORALLY DISINTEGRATING TABLETS (ODTS) OF CEFPODOXIME PROXETIL USING ION EXCHANGE RESINS
Urinary and respiratory tract infections are common incidences in children for which Cefpodoxime proxetil is a choice of drug .However the bitter taste of the drug limits its use, due to which conventional oral formulati...
FLOATING MULTIPARTICULATE SYSTEMS: A NOVEL APPROACH IN GASTRORETENTIVE DRUG DELIVERY SYSTEMS
Abstract Recent advances in novel drug delivery system to enhance the safety and efficacy of the drug molecule by formulating a dosage form being convenient for administration. A controlled drug delivery system with prol...
A PERSPECTIVE REVIEW ON HOMALIUM ZEYLANICUM BENTH
Abstract Plant Homalium zeylanicum Benth belongs to Flacourtiaceae family and is distributed in evergreen and semi-evergreen forests, native to south India and srilanka.It is also found in Bangladesh, Laos. Myanmar, Nepa...
IMPACT OF CLINICAL PHARMACIST MEDIATED CARE IN DIABETES MELLITUS - A NEW COMMUNITY BASED MODEL OF CARE
Abstract AIMS: The main Aim of the study is to evaluate the impact of clinical pharmacist care in improving glycemic control, HRQOL, medication adherence in type 2 Diabetes mellitus patients. METHODS: The study is conduc...