A VALIDATED SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE AND LEVOCETIRIZINE DIHYDROCHLORIDE IN TABLET FORMULATIONS
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
A simple, precise and accurate spectrophotometric method was developed for simultaneous estimation of Ambroxol HCl and LevoCetirizine DiHCl in bulk and tablet dosage form. This method is based on use of Derivative method for simultaneous estimation of both the drug from tablet and Distilled water is used as solvent. Ambroxol HCl shows maximum absorption at 244nm and LevoCetirizine DiHCl shows absorption at 231 nm. Ambroxol HCL and LevoCetirizine HCl obeys Beer,s law in the concentration range 0-32 ug/ml and 0-30ug/ml respectively.During estimation of Tablet no interference was found from excipients. The dosage form contains 60 mg Ambroxol HCl and 5 mg LevoCetirizine DiHCl.The suitability of this method for estimation of both drugs was proved by validation. Statistical analysis data shows that the developed method is sound under analytical condition and can be used for routine analysis of both drugs.
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- EP ID EP331035
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