Abstract

Urinary and respiratory tract infections are common incidences in children for which Cefpodoxime proxetil is a choice of drug .However the bitter taste of the drug limits its use, due to which conventional oral formulations suffer the drawback of rejection by pediatric population. Hence to improve patient compliance, Orally Disintegrating Tablet (ODT) containing taste masked cefpodoxime was formulated. The first step of taste masking was achieved by complexation of the drug with various ion exchange resins like Kyron T-104, T-114, T-134 and T-154. After optimization of process and formulation parameters, the final complex was evaluated for in-vitro drug release, swelling studies DSC, XRD, NMR studies and was selected to be formulated into ODT. The concentrations of the tabletting excipients were optimized by 32 full factorial design. The formulation with Kyron T-314 at concentration of 5% and diluent blend of Pharmaburst: MCC in the ratio of 1:2 was selected as optimum with a disintegration time of 11 seconds which was a major outcome in designing elegant ODTs with a rapid disintegrating nature. The SEM of the tablet cross section showed presence of hollow spaces. The negligible release of drug in salivary pH helped to conclude that ion exchange is an effective approach of taste masking. Optimized formulations were found to be stable after 3 months accelerated stability studies.

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