Formulation and Evaluation of Oro Dispersible Tablets of Famotidine using Superdisintegrants
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
The objective of the present investigation was to prepare oro dispersible tablets of Famotidine, because of their convenience in administration and suitability for patients having dysphagia. Tablets were prepared by direct compression using sodium starch glycolate and croscarmellose sodium and crospovidone as superdisintegrants. Microcrystalline cellulose pH-102 was used as diluent and mannitol, sodium saccharine to enhance the organoleptic properties of tablets. The tablets were evaluated for weight variation, hardness, friability, assay, in-vitro disintegration time, in-vitro dissolution study. Hardness and friability data indicated good mechanical strength of tablets. The results of in-vitro disintegration time indicated that the tablets dispersed rapidly in mouth within 60 seconds. It was concluded that superdisintegrants addition technique is a useful method for preparing oro dispersible tablets by direct compression method.
Authors and Affiliations
Vyomesh N. Raval, Gajanan J. Deshmukh, A. K. Seth, Tejas K Ghelani, Sharad Kumar, Hemangi Patel, Sachin Chauhan
Keywords
Related Articles
- EP ID EP221878
- DOI -
- Views 205
- Downloads 0
KINETICS AND MECHANISM OF OXIDATION OF AZO DYE ACID YELLOW 36 BY CHLORAMINE-T IN HYDROCHLORIC ACID MEDIUM
Abstract Kinetics of oxidative decolorization of Acid yellow36 (AY36) by chloromine-T,(CAT) in hydrochloric acid (HCl) medium at 301 K has been investigated spectrophotometrically at λmax439nm. The reaction showed first...
Development and Validation of Spectroscopic Method for Simultaneous Estimation of Acebrophylline and Montelukast Sodium in Combined Dosage Form
A novel combination of Acebrophylline and Montelukast Sodium is used in the treatment of chronic obstructive pulmonary disease (COPD) and bronchial asthma. A simple, sensitive, accurate and reproducible spectroscopic met...
ASSESSMENT OF PMTCT SERVICE QUALITY AT BEDDELLE AND METTU KARL HOSPITALS, IN ILU ABABORA ZONE OROMIYA REGION, SOUTH WEST ETHIOPIA.2015
Abstract Background: - Globally, there are an estimated 34 million people living with HIV (PLHIV), the vast majority of who live in sub-Saharan Africa and every day over 5700 persons die from AIDS. Mother-to-Child Transm...
TOTAL PHENOLIC CONTENTS AND ANTIOXIDANT ACTIVITY OF METHANOL EXTRACT FROM LEAVES, FLOWERS AND STEMS OF WARIONIASAHARAEL. FROM MORROCCO
The phenolic contents of metabolic extracts of WarioniasaharaeL leaves, flowers and stems from Morocco were measured in this work. The antioxidant activities of these extracts were also evaluated. The leaves methanolextr...
FORMULATATION DEVELOPMENT AND EVALUATION OF EFFERVESCENT TABLET OF PARACETAMOL AND N-ACETYLCYSTEINE.
Abstract The main aim of the work is to design and develop stable formulation of effervescent tablets of Paracetamol and N-Acetylcysteine and to evaluate respective formulation. The present work is directed to a new phar...