Development and characterization of Microemulsion based system of Aceclofenac
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
The objective of the present study was to incorporate poorly soluble Aceclofenac (ACF) into microemulsion based formulation. In present study microemulsion was prepared with 6% w/w Isopropyl Myristate (IPM), 27%w/w Tween 80 & 18%w/w PEG-400 as oil, surfactant & Cosurfactant respectively. The ratio of surfactant: cosurfactant was fixed at 4:1 on the basis of Ternary phase diagram. Microemulsion gel was prepared using 1% Carbopol 934 as a gelling agent. Optimized formulation was evaluated for drug content, zeta potential, droplet size, drug assay, pH, viscosity, in-vitro drug release profile and stability study. Globule size of optimize batch ACF 5 was found to be 11.52 ± 0.6 nm. In vitro release study had shown 25.55 ± 2.39 % drug release from microemulsion gel which was more compared to marketed product. Optimize batch ACF 5 was found stable throughout stability study for two months at different temperature (2-8°c & room temperature).
Authors and Affiliations
N. V. Shah, T. K Ghelani, Vipin Saini, U. T. Joshi, A. K. seth, S. P. Chauhan, C. J. Aundhia, R . A. Maheshwari
Keywords
Related Articles
- EP ID EP221896
- DOI -
- Views 113
- Downloads 0
BURDEN OF LEFTOVER MEDICATION AT HOME AND ITS CONTRIBUTING FACTORS IN GOBA TOWN, BALE ZONE, ETHIOPIA
Abstract Background: Essential medicines save lives, reduce suffering and improve health. However keeping unwanted or expired medications in house potentially exposes the family to risks. Patients may not use all the med...
QUALITY AND TREATMENT OUTCOMES OF DIRECTLY OBSERVED TREATMENT OF SHORT-COARSE OF TUBERCULOSIS (DOTS) IN SOUTH WEST ETHIOPIAN: A COHORT STUDY
Abstract Background: TB is one of the world’s leading causes of death and of the global burden of disease. It is estimated that at 36 million will die of TB if proper control measures are not instituted. Assessing the qu...
EVALUATION OF THE ANXIOLYTIC ACTIVITY OF CURCUMIN AGAINST LEAD INDUCED ANXIETY IN RATS
Abstract Present research work was performed to evaluate the anxiolytic activity of curcumin against lead induced anxiety in rat. Anti-anxiety potentials of the curcumin were compared with diazepam. Lead poisoning induce...
ETHOSOMAL DRUG DELIVERY SYSTEM: A REVIEW
The vesicles have been well known for their important in cellular communication and particle transportation for many years. Researchers have understood the properties of vesicle structures for use in better drug delivery...
METABOLITE ANALYSIS OF HUGONIA MYSTAX L. (LINACEAE) LEAVES FROM SOUTH-WEST REGION OF INDIA
Hugonia mystax Linn., is an ethanobotanically important plant which plays a vital role in primary healthcare of tribals from Tiruvannamalai hills, Tamil Nadu, India. There is paucity in the literature regarding the activ...