ABC membrane transporters and their multifunctional nature
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2018, Vol 72, Issue
Abstract
ABC transporters are the largest family of transport proteins, which mediate the active translocation of a wide spectrum of molecules through the cell membrane, using energy from hydrolysis of ATP. They can act as importers (in Procaryota exclusively) or exporters (in both Procaryota and Eucaryota) of specified substrates. Despite a quite conservative structure model, ABC transporters are diverse in terms of functions performed in the body. These proteins are important elements of the blood-organ barriers, they maintain lipid homeostasis, participate in cellular immune response but also are involved in the development of multidrug resistance as well as affect the biology of tumour cells. Additionally, they play the role of ion channels or regulators of their activity. The activity of ABC transporters is also correlated with the occurrence of certain disease entities, such as cystic fibrosis, Dubin-Johnson syndrome, Tangier disease, persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and neoplasia. Due to their therapeutic potential, ABC transporters are becoming increasingly popular. Knowledge of the mechanisms of action of ABC transporters and their regulatory systems will provide the basis for the development of personalized medicine, which may be significant especially in the context of cancer treatment.<br/><br/>
Authors and Affiliations
Magdalena Smolik, Joanna Suraj, Anna Kurpinska, Maria Walczak
Keywords
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