Vitamin D – a new look in medicine and rheumatology
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
The research of the last decade pointed to the importance of vitamin D not only in bone metabolic processes, but also in immunologic and anticarcinogenic processes. Thus, its common insufficiency is related to serious health consequences – e.g. increased mortality and morbidity caused by autoimmune and cancer diseases. The modification of the range of values of vitamin D serum concentration and revision of its nutritional and pharmacological recommendations are suggested nowadays. Moreover, the discovery of the vitamin D receptor (VDR) enables us to understand its influence on other organs. To date the new properties of vitamin D are elucidated in the literature showing its preventive effect and possible application in supportive treatment of many diseases.
Authors and Affiliations
Bogna Grygiel-Górniak, Mariusz Puszczewicz
When defense becomes dangerous – transcription factor Nrf2 and cancer
The transcription factor Nrf2 controls the expression of genes encoding cytoprotective enzymes and proteins. Its activation is related to conformational changes in the inhibitory protein Keap1 and/or Nrf2 phosphorylation...
Rola mikrośrodowiska szpiku kostnego w patogenezie szpiczaka plazmocytowego
Szpiczak plazmocytowy (multiple myeloma, MM) jest jednym z najczęstszych złośliwych nowotworów hematologicznych. Pozostaje nadal chorobą nieuleczalną. Od dziesięcioleci podstawą leczenia była niecelowana terapia z zastos...
Short-term exposure to ambient fine particulate matter (PM2,5 and PM10) and the risk of heart rhythm abnormalities and stroke
Results of epidemiological studies suggest a significant impact of ambient particulate matter air pollution (PM10 and PM2,5) on the health of the population. Increased level of these pollutants is connected with increase...
The role of the Fanconi anemia pathway in DNA repair and maintenance of genome stability
The Fanconi anemia (FA) pathway is one of the DNA repair systems involved in removal of DNA crosslinks. Proteins which belong to this pathway are crucial to the protection of genetic information, whereas disturbances in...
Radiation hygiene in interventional radiology suite
Exposure of both patients and medical staff to relatively high doses of radiation is one of the features characteristic of interventional radiology (IR). Regulations regarding this kind of therapeutic management can be f...