Accelerated maturation of peripheral blood lymphocytes in children with primary hypertension
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 11
Abstract
Introduction. Primary hypertension (PH) is associated with immune activation. Theisoforms of leucocyte common antigen (CD45) in the CD4 and CD8 T cell subsets aremarkers of T cells status. Naive cells express the RA+ isoform and memory cells expressthe RO+ isoform. The profile of CD45 isoforms may serve as the marker of T cells functionalstatus and senescence.Aim. Analysis of distribution of T lymphocytes bearing CD45RA+ (naive) andCD45RO+ (memory) markers and their relationship with hypertension severity and targetorgan damage (TOD).Material and methods. 68 children with PH (15.6 ± 2 years, 59 boys) and controlgroup of 26 (14.8 ± 3.7 years, 19 boys) children. The expression of CD45RA+ andCD45RO+ isoforms in the CD4 and CD8 T cell subset was evaluated by flow cytometrytechnique.Results. Hypertensive children had greater intensity and percentage of CD45RO+CD4and CD8 T lymphocytes and lower RA+/RO+ ratio of CD4 and CD8 lymphocytes thancontrols. T lymphocytes markers expression did not correlate with carotid intima-mediathickness.Children with left ventricular hypertrophy had less CD45RA+CD4 T cells, moreCD45RO+ CD4 T cells and lower ratio of RA+/RO+CD4 cells than PH children with normalleft ventricular mass index. The percentage of CD45RA+CD8 T cells decreased with increasingblood pressure status from prehypertension, ambulatory hypertension to severeambulatory hypertension.Conclusions. PH children had less naive T lymphocytes and more T cells with ‘memoryphenotype’. These alterations correlated with hypertension severity and TOD.
Authors and Affiliations
Anna Niemirska, Jacek Michałkiewicz, Mieczysław Litwin
Keywords
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- DOI 10.5604/08606196.1190903
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