Acquired Pure Red Cell Aplasia caused by Parvovirus B19 Infection following a Renal Transplant
Journal Title: Sultan Qaboos University Medical Journal - Year 2011, Vol 11, Issue 2
Abstract
We report a young Omani male who developed severe and persistent anaemia after a kidney transplantation while being on immunosuppression therapy, standard practice to prevent rejection of the transplanted kidney. His bone marrow aspirate showed the classic morphological changes of pure red cell aplasia (PRCA), induced by parvovirus B19 infection which is the presence of giant proerythroblasts with viral inclusions. Te virus was also demonstrated by polymerase chain reaction in the blood along with IgM antibodies to parvovirus B19. He responded dramatically to high dose immunoglobulin with a normalisation of his haemoglobin level in two weeks and remained normal until seven months later. Parvovirus B19 induced PRCA can be cured. Tis aetiology must be kept in mind especially when a chronic anaemia, refractory to treatment, is accompanied by a reticulocytopenia. Te latter reflects the lysis of the proerythroblasts, preventing maturation of the erythroid cells causing anaemia. Early recognition and prompt treatment spares the patient unnecessary exposure to blood transfusions, erythropoietin and renal disease caused by the virus. PRCA secondary to parvovirus B19 infection following kidney transplantation is reported in the literature, but not in the Omani population. To the best of our knowledge, this is the frst such report in Oman.
Authors and Affiliations
Arundathi Kurukulasuriya| Department of Hematology & Blood Transfusion, Royal Hospital, Muscat, Oman, Amal A. Hamed| Department of Hematology & Blood Transfusion, Royal Hospital, Muscat, Oman, Muhanna Al-Muslahi| Department of Hematology & Blood Transfusion, Royal Hospital, Muscat, Oman, Asaid Ibrahim| Department of Nephrology, Sohar Hospital, Oman
Keywords
Related Articles
- EP ID EP14057
- DOI -
- Views 289
- Downloads 8
Neurology Research in Saudi Arabia Urgent call for action
Objectives: Research activities in Saudi Arabia are promoted at the governmental and institutional levels. However, the output and quality of research conducted in the feld of neurology has not yet been measured quanti...
Lead Toxicity due to Ingestion of Lead-Contaminated Opium in a Patient Presenting with Motor Neuropathy and Upper Limb Paresis: A case report
Opium users may present with central or peripheral nervous system-related symptoms, gastrointestinal complications and anaemia; in such cases, lead poisoning should be suspected and chelation therapy initiated as soon as...
Contraceptive Utilisation Among Mothers of Reproductive Age in Ajman, United Arab Emirates
Objectives: Tis study aimed to determine contraceptive utilisation among mothers aged 18–49 years old in Ajman, United Arab Emirates (UAE). Methods: Tis cross-sectional study was carried out from May to November 2013...
Effectiveness of Hemcon Dental Dressing versus Conventional Method of Haemostasis in 40 Patients on Oral Antiplatelet Drugs
Objectives: Te purpose of the study was to evaluate the effectiveness of the HemCon Dental Dressing (HDD) in controlling post extraction bleeding and to ascertain its role in healing of extraction wounds, as compared...
The Role of Damage-Associated Molecular Patterns in Human Diseases Part I - Promoting inflammation and immunity
Tere is increasing interest by physicians in the impact of the innate immune system on human diseases. In particular, the role of the molecules that initiate and amplify innate immune pathways, namely damage-associated...