ACTIVE PHENOLIC CONSTITUENTS AND BRINE SHRIMP LETHALITY ASSAY OF HYDROALCOHOLIC EXTRACT OF Plectranthus amboinicus
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2017, Vol 10, Issue 2
Abstract
Objective: Plectranthus amboinicus, (PA) leaves contain pharmaceutically important phyto constituents that attribute to greater medicinal values. The purpose of the present study was to investigate the active principles present in the potent Hydroalcoholic extract of P.amboinicus and brine shrimp lethality studies to understand the toxicity profile of PA.Methods: An approach towards High performance liquid chromatography (HPLC) screening of Hydroalcoholic extract of P.amboinicus and selective partitioning using various solvents such as Hexane, chloroform, ethylacetate and butanol were performed to identify the active principles present. Acute oral toxicity or brine shrimp lethality studies on Artemia salina L. using active fraction of PA were also attempted.Results: The HPLC profile of ethylacetate fraction of Hydroalcoholic extract showed flavonoids such as Rutin, quercetin, luteolin and gallic acid, which was found to be considerably different from Hydroalcoholic extract and this fraction also showed good acute oral toxicity effect and the LC50 value obtained was 198.630µg/ml.Conclusion: These results attribute to the pharmacological importance of the plant. Selective Isolation of individual phytochemical constituents and subjecting it to biological testing will definitely give promising results for medicinal field.
Authors and Affiliations
Dayana Janakiraman, Parameswari Somasundaram
Keywords
Related Articles
- EP ID EP605429
- DOI 10.22159/ajpcr.2017.v10i2.15115
- Views 87
- Downloads 0
A REVIEW ON PSYCHOSIS AND ANTI-PSYCHOTIC PLANTS
ABSTRACTPsychosis (schizophrenic, schizoaffective, and affective illnesses) is a group of serious illnesses that affect the mind. About 1% of the population suffersfrom psychosis worldwide and increases for those, whose...
PHARMACOLOGICAL IMPORTANCE OF MORINGA CONCANENSIS NIMMO LEAF: AN OVERVIEW
In the current years, the use of traditional medicine is increasing and gaining popularity. The extracts of Moringa concanensis Nimmo leaves have reported many medicinal uses. In the previous few decades, a massive quant...
PREVALENCE OF HYPERTENSION AMONG ADULT POPULATION IN SLUMS OF WEST DELHI
Objective: The present study was conducted to assess the prevalence of hypertension in adult population residing in slums of West Delhi.Methods: A cross-sectional study was conducted among adult population of 18-59 years...
FICUS CARICA AND ITS CONSTITUENTS ROLE IN MANAGEMENT OF DISEASES
Alternative medicines or formulation based on natural sources are good option in diseases cure and prevention. Ficus carica is member of Moraceae family and its health management properties have been mentioned in religio...
EFFICACY OF CHONDROITIN SULFATE WITH GLUCOSAMINE VERSUS DIACEREIN IN GRADE II AND III OSTEOARTHRITIS KNEE: A RANDOMIZED COMPARATIVE STUDY
ABSTRACTObjective: Osteoarthritis (OA), the most common joint disease has led to great morbidity and disability. Symptomatic slow acting drugs for OA, whichincludes glucosamine sulfate, chondroitin sulfate, and diacerein...