ACTIVITY OF ALKALINE PHOSPHATASE AS A MARKER OF PARANEOPLASTIC RHEUMATOLOGICAL SYNDROME IN LUNG CANCER PATIENTS
Journal Title: Ukrainian Scientific Medical Youth Journal / Український Науково-Медичний Молодіжний Журнал - Year 2012, Vol 70, Issue 4
Abstract
The activity of alkaline phosphatase was investigated in the blood serum of 171 patients with lung cancer who were under treatment for cancer, of which 76 (44.4%) patients were with paraneoplastic rheumatological symptoms. It was found that the activity of alkaline phosphatase can serve as a reliable marker of rheumatological paraneoplastic syndrome in patients with lung cancer. It was found that the activity of alkaline phosphatase in lung cancer patients with this syndrome is 2.86 times higher than in patients without symptoms and drastically changes depending on the treatment (operative – the decrease in the index by 2.47 times, during conservative or without treatment – increase by 1.36 and 1.7 times, respectively). Hence, the surgical treatment of lung cancer leads to suppression of manifestations of paraneoplastic rheumatological syndrome, during conservative anti-tumor treatment – to stabilization of the symptoms, and if there is no specific treatment it leads to progression of the given syndrome.
Authors and Affiliations
S. A Lysenko , À. V. Melnik , R. G. Tserkovniuk
Keywords
Related Articles
- EP ID EP111187
- DOI -
- Views 84
- Downloads 0
ROLE OF BLOOD LIPID SPECTRUM DETERMINATION IN PATIENTS WITH CHRONIC HEPATITIS C
45 patients with chronic hepatitis C were examined. It was shown, that the majority of them had significant impairment of lipid metabolism. Some indices of lipid metabolism correlated with viral genotype, viral loading,...
THE EFFECTS OF APPLICATION OF NITRIC OXIDE DONOR IN CASE OF IMPAIRMENT OF RENAL EXCRETORY FUNCTION ON CLINICAL EFFICACY OF TREATMENT OF NEWLY DIAGNOSED PULMONARY TUBERCULOSIS
The paper presents the research on clinical efficacy of treatment of newly diagnosed pulmonary tuberculosis with application of nitric oxide donor for the purpose of renoprotection of patients with primary impairments of...
ROLE OF UROCANIC ACID IN THE PATHOGENESIS OF PSORIASIS
The article presents a review of current literature on the role of immune mechanisms in the pathogenesis of psoriasis. Among them, much attention is paid to urocanic acid, which provides a natural protection of the skin...
ORGANIZATION OF INDEPENDENT STUDENTS WORK FOR ENGLISH SPEAKING STUDENTS TO SUBJECT “HUMAN ANATOMY” AND WAYS OF ITS PERFECTING
The results of researches permit to introduce into practice for the english-speaking students of the highest medical (pharmacological) educated institutes clustered system of teaching human anatomy and standard control o...
PATHOMORPHOLOGICAL DIAGNOSTIC FEATURES OF THE SOFT TISSUE TUMORS
On the basis of immune-hystochemical examination of two suspicious cases of fibrosarcoma with using of the antibodies to vimentin, CD 99, S-100 protein, EMA (epithelial membrane antigen), 7 and 19 cytokeratines, monophas...