Activity of Caprine CSN1S2 Protein Reducing the COX-2 and IL-17 Expression of Aorta Tissue in Type 2 Diabetes Mellitus Rat
Journal Title: Journal of Mathematical and Fundamental Sciences - Year 2018, Vol 50, Issue 3
Abstract
Type 2 diabetes mellitus (T2DM) is a degenerative disease that leads to increased inflammation and cyclooxygenase protein production, which causes tissue abnormalities. The aim of this study was to determine the effect of caprine CSN1S2 protein against abnormal metabolic pathways in the aorta of DM rats. The twenty-four-animal model was control, diabetes and treatment groups. Histopathological evaluation of the aortic tissue by hematoxylin eosin staining. The expression of cyclooxygenase and inflammatory cytokine was measured by western blotting. In the DM750 groups, the amount of discontinued-endothelial was significantly more reduced than in the other groups. The amount of macrophages in the DM1500- group decreased more than in the DM and DM375 groups. The amount of foam cells in the DM750 and DM1500 groups decreased more than in the DM group and was close to all control groups. The expressions of COX-2 and IL-17 were effectively reduced and vice versa the expression of IL-10 was increased in DM750 compared with the other groups. Meanwhile, COX-1 expression did not change in all groups. This study indicates that caprine CSN1S2 protein at a dose of 750 mg/kg BW has a significant effect on controlling, protecting, and repairing abnormalities in the aortic tissue of T2DM rats.
Authors and Affiliations
Yoga Tribakti Rachmad, Titin Andri Wihastuti, Katsuhiro Miyajima, Fatchiyah Fatchiyah
Keywords
Related Articles
- EP ID EP541530
- DOI 10.5614/j.math.fund.sci.2018.50.3.8
- Views 107
- Downloads 0
Local Fractional Operator for a One-Dimensional Coupled Burger Equation of Non-Integer Time Order Parameter
In this study, approximate solutions of a system of time-fractional coupled Burger equations were obtained by means of a local fractional operator (LFO) in the sense of the Caputo derivative. The LFO technique was built...
Approximate Solutions of Linearized Delay Differential Equations Arising from a Microbial Fermentation Process Using the Matrix Lambert Function
In this paper we present approximate solutions of linearized delay differential equations using the matrix Lambert function. The equations arise from a microbial fermentation process in a metabolic system. The delay term...
Riesz Representation Theorem on Bilinear Spaces of Truncated Laurent Series
In this study a generalization of the Riesz representation theorem on non-degenerate bilinear spaces, particularly on spaces of truncated Laurent series, was developed. It was shown that any linear functional on a non-de...
On a Certain Subclass of Meromorphic Functions Defined by a New Linear Differential Operator
In this article, a new linear differential operator I^k (L_s^a (a_l,b_m )f(z)) is defined by using the Hadamard product of the q-hypergeometric function and a function related to the Hurwitz-Lerch zeta function. By using...
Assessing Resistance and Bioremediation Ability of Enterobacter sp. Strain Saw-1 on Molybdenum in Various Heavy Metals and Pesticides
One of the most economical approaches for removal of toxic compounds is bioremediation. In the long term, bioremediation is economic and feasible compared to other methods, such as physical or chemical methods. A bacteri...