Activity of lysosomal enzymes in the liver and kidneys of mice after morphine administration
Journal Title: Animal Science Papers and Reports - Year 2010, Vol 28, Issue 2
Abstract
Used were ninety Swiss mice males divided into 9 groups (n=10). Three control groups [I, II, III] were injected with 0.9% NaCl solution, while six experimental groups (A, B, C, D, E, F) with the morphine hydrochloride. Mice from groups A, C and E were injected with a dose of 20 and those from B, D and F with a dose of 30 mg morphine per kg body weight. In each group, both solutions were administered intramuscularly once a day from 9:00 to10:00 a.m. for 4, 10 and 14 days. In the lysosomal fraction of the liver and kidney the activities of cathepsin D, cathepsin L, alanine aminopeptidase, leucine aminopeptidase, lysosomal lipase, and β-glucosidase were estimated. Morphine led to the increased activity of all examined enzymes except lysosomal lipase, the activity of which dropped in both organs examined.
Authors and Affiliations
Bożena Witek, Ewa Ochwanowska, Artur Wróbel, Adam Kołątaj
Keywords
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