ACTIVITY OF N-ALKYL ARYL AMINOPROPANOL DERIVATIVES ON STAPHYLOCOCCUS BIOFILMS
Journal Title: Молодий вчений - Year 2017, Vol 11, Issue 51
Abstract
Nowadays there are no antibacterial medications in clinical practice, effective against biofilms at non-toxic doses for human. Our studies have shown the significant antibiofilm effect of aminopropanols with N-alkyl aryl radical. Compound KVM-194 possessed the most pronounced activity against the preformed S. aureus biofilms at subinhibitory concentration; its action was superior or comparable to referent antimicrobials ciprofloxacin, azithromycin, gentamicin, rifampicin. The data obtained suggest the promises of novel aminopropanol derivatives with N-alkyl aryl radical for the development of new antibiofilm drugs.
Authors and Affiliations
N. I. Hrynchuk
Keywords
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