Acute and Long -Term Toxicity Study of Poora Parpam a Herbo – Mineral Siddha Drug
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 7
Abstract
Safety is the fundamental principle in the provision of traditional medicine and herbal products. As siddha medicine is gaining pace everywhere, it is essential to prove the safety of all drugs. According to siddha literature poora parpam is efficient in the management of arthritis and its related complications. Since it is a mercurial drug it is mandatory to study its toxicity profile. Acute and long term toxicity studies were carried out in swiss albino mice and wistar albino rats following WHO guidelines mentioned for traditional herbal medicines. In acute toxicity study 10 times more than the therapeutic dose of drug prescribed was given as single oral dose to the test animals and no sign of mortality was observed. Long term toxicity studies were carried out in different groups in which test drug was administered orally to rats at dose levels of 0.1296 mg/ animal, 0.648 mg/ animal and 1.296 mg/ animal respectively. Detailed hematological, biochemical, morphological and histopathological evaluation of organs was performed for all animals at the end of the study. Haematogical and biochemical analysis revealed no abnormalities. Histopathological analysis of brain, heart, kidney, liver, lungs of treated groups does not show any signs of toxicity. Thus Poora parpam was well tolerated by the treated groups and showed the therapeutic dose mentioned in the literature was safe for human consumption.
Authors and Affiliations
*Rajmohan M S, Swetha R, Sowmiya S
Keywords
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- EP ID EP569679
- DOI 10.22192/ijcrms.2017.03.07.019
- Views 130
- Downloads 0
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