ACUTE AND SUB-CHRONIC TOXICOLOGICAL STUDIES ON METHANOLIC STEM EXTRACT OF ACALYPHA INDICA LINN IN ALBINO WISTAR RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: The present study was aimed to investigate safety evaluation studies of methanolic stem extract of A. indica (AIS-ME) through acute and sub-chronic toxicity studies in albino wistar rats.Methods: Acute toxicity test was carried out in albino wistar rats by single dosage administration of 500, 1000 and 1500mg/kg body weight of AIS-ME and observed for mortality and behavioural changes for a period of 24h. Sub-chronic toxicity studies were conducted by an oral administration of 100mg/kg body weight AIS-ME in albino wistar rats for a period of 30 consecutive days. Rats in sub-chronic toxicity studies were checked for body weight once in a week for 30 days and at the end of the experimental period, blood samples were collected for hematological and biochemical parameters. Organs (Liver and Kidney) were harvested and histological sections were made to examine for any organ damage after the treatment of AIS-ME.Results: Acute toxicity study resulted in no mortality and behavioural changes even at the post oral dosage of 1500mg/kg body weight of AIS-ME. Sub-chronic toxicity revealed no significant changes in body weight, hematological and biochemical parameters of treated groups in comparision with the control groups. Histological sections of treated groups resulted in similar architecture as that of nomal groups suggesting no morphological damages of the internal organs.Conclusion: This study concluded that AIS-ME is non toxic as per the results of acute and sub-chronic toxicity studies. Thus, it could be considered as a safe phytomedicine for oral administration in experimental rats.Â
Authors and Affiliations
K V Bhaskara Rao, Charles Lekhya Priya
Keywords
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