EFFECT OF TERMINALIA CHEBULA (HARAD) FRUIT EXTRACT ON CARDIOTOXICITY IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 9
Abstract
Objective: The aim of the study was to explore the protective activity of Terminalia chebula fruit extract on cardiotoxicity in streptozotocin (STZ) induced diabetic rats.Methods: The animals were divided into eight groups of five each and were fed with high fat diet (HFD) except sham control, diabetic control and isoproterenol control. Diabetes was induced by administering single intraperitoneal (i. p.) injection of STZ (0.05 g/kg) in all groups except sham and isoproterenol control and was confirmed by testing blood glucose level after 48 h. Rats were pretreated with ethanolic extract of Terminalia chebula (0.25& 0.5 g/kg/d; per oral (p. o.)), pioglitazone (0.01 g/kg/d), carvedilol (0.002 g/kg/d) and normal saline throughout the study period (14 days). Cardiotoxicity was induced by the administrating two subcutaneous (s. c) injection of isoproterenol (ISO) (0.085 g/kg) at an interval of 24 h. Troponin was checked to confirm cardiotoxicity. The evaluation parameters include initial and final blood glucose level, change in body weight, food efficiency ratio (FER), heart weight-body weight ratio, biochemical estimations and histopathological studies.Results: Pretreatment with Terminalia chebula produced significant (p<0.01) decrease in blood glucose level and heart weight-body weight ratio. It significantly decrease the elevated activity of the cardiac marker enzymes, alanine transaminase (ALT), lactate dehydrogenase (LDH), creatinine kinase (CK-MB) (p<0.01), similar to the standard drug carvedilol in isoproterenol injected rats. Pretreatment with Terminalia chebula showed absence of troponin and lesser degree of necrosis, edema, and myofibrillar degeneration.Conclusion: Terminalia chebula has significant cardioprotective action against cardiotoxicity in STZ induced diabetic rats, which is comparable with standard drugs i.e., pioglitazone and carvedilol.Â
Authors and Affiliations
Supriya Roy, Tarique Mahmood, Hefazat Hussain Siddiqui, Paramdeep Bagga, Arshiya Shamim
Keywords
Related Articles
- EP ID EP578450
- DOI -
- Views 80
- Downloads 0
SCAR MARKER DEVELOPMENT FOR THE CORRECT IDENTIFICATION OF IRIS ENSATA
Objective: The objective of this research was to develop the RAPD based SCAR marker for the correct identification of the Iris ensata Thunb. (I. ensata) plant from its adulterants.Methods: Five samples of I. ensata. from...
BIOCHEMICAL EFFECT OF A HIGH DOSE OF THAUMATIN IN WISTAR RATS
Objective: The aim of this work was to investigate the capability of a high dose of thaumatin; a sweet tasting protein, of improving induced protein malnutrition in male Wistar rats.Methods: For this study, 12 rats were...
IN VITRO EVALUATION OF DISSOLUTION PROFILE OF TWO COMMERCIALLY AVAILABLE FOLIC ACID PREPARATIONS
Objectives: Folic acid is a water-soluble B vitamin that is naturally present in some foods such as dark green leafy vegetables and dairy products, added to others such as fortified breads, and available as a dietary sup...
MUTANT P21 PEPTIDES COULD ACT AS AN IMPROVED CYCLIN A INHIBITORS FOR CANCER THERAPY: AN IN SILICO VALIDATION
Objective: The present study delineates the generation of mutant peptide library from a known anticancer peptide, p21 and in silico evaluation for their affinity towards cyclin. A substrate binding groove. Methods: Muta...
STARZ-DRP: A STRUCTURED FRAMEWORK FOR TEACHING COMMUNITY PHARMACISTS TO COUNSEL SELF-CARE CUSTOMERS
Objective: Aim of this study is to take a look at the community pharmacists’ (CPs) self-rating confidence of advocating self-care customers using before and after attending a STARZ-DRP training workshop.Methods: CPs (n...