ACUTE AND SUBACUTE TOXICITY STUDIES OF INDIGOFERABARBERI GAMBLE, AN ENDANGERED MEDICINAL PLANT
Journal Title: Journal of Pharmaceutical and Scientific Innovation - Year 2018, Vol 7, Issue 6
Abstract
Indigofera barberi Gamble, is a shrub used for various therapeutic activities in traditional system of medicine including liver disease. In this paper, we have evaluated the acute and subacute toxicity studies of crude extracts of Indigofera barberi Gamble. Indigoferabarberi was administered in doses from 100 to 2000 mg/kg (single dose) for the acute toxicity study. In subacute toxicity test animals were administered 500 and 1000 mg/kg doses by orally for 28 consecutive days.The subacute toxicity study of Indigoferabarberi did not reveal alterations in body weight, food and water consumptions. The haematological parameters, relative organ weights, biochemical and lipid profile analyses did not show any significant differences between control and treated groups. No abnormalities or histopathological changes were observed in the liver cells of all treated groups.The study concluded that administration of Indigoferabarberi in wistar albino rats is nontoxic and is safe for use.
Authors and Affiliations
Srinivasan N
Keywords
Related Articles
- EP ID EP631518
- DOI 10.7897/2277-4572.076115
- Views 56
- Downloads 0
TECHNICAL SHEET FOR IMPROVING POST HARVEST STORAGE AND CONSERVATION OF KOLANUTS
Kolanut is one of the most popular fruits in traditional ceremonies in Africa and it has great added value when it is well preserved for a long time. However, we found lot of losses during storage due to handlingand poor...
EXPERIMENTAL EVALUATION OF KADALIKANDA PANEEYA KSHARA VIŚ - Á - VIŚ ASHMARIGHNA PROPERTY
The present study was aimed to evaluate the Ashmarighna(antiurolithiatic) property of KadalikandaKshara(Test drug) against ethylene glycol (1%) induced urolithiasis in Wistar albino rats.Animals were divided into five gr...
FORMULATION AND EVALUATION OF CAPSULES OF SYZYGIUM CUMINI PHYTOSOMES
The objective of the study was to develop a novel Phytosome formulation of Syzygium cumini capsules by incorporation of phospholipids, for the improved permeability, solubility and better physical characteristics.The Syz...
AN INVESTIGATION ON NANO METAL VITAMIN COMPLEX TO CONTROL OXIDATIVE CELL DAMAGE AND MICROBIAL SPOILAGE IN SEAFOOD
Fish is considered to be one of the most-traded food commodities worldwide with more than half of fish exports by value originating in developing countries. In order to increase its shelf life and maintain its nutritiona...
IN VITRO STUDY OF ENDOPHYTIC BACTERIA BACILLUS CEREUS FROM TULSI LEAF AGAINST ESCHERICHIA COLI IN KAPHAJA PRATHISHYAYA
Kaphaja Pratishyaya is a frequently observed respiratory diseaseshows typical Ghana-Shwetha-Snigdha-Srava (thick-whitish-mucoid discharge)characteristic features of Nasa Srava (nasal discharge). Among the microbial flora...