EXPERIMENTAL EVALUATION OF KADALIKANDA PANEEYA KSHARA VIŚ - Á - VIŚ ASHMARIGHNA PROPERTY
Journal Title: Journal of Pharmaceutical and Scientific Innovation - Year 2018, Vol 7, Issue 1
Abstract
The present study was aimed to evaluate the Ashmarighna(antiurolithiatic) property of KadalikandaKshara(Test drug) against ethylene glycol (1%) induced urolithiasis in Wistar albino rats.Animals were divided into five groups as six animals in each group. First group served as normal control and received regular rat food and drinking water. Ethylene glycol (1%) was given in drinking water were fed to all other groups (Group 2 – 5). 2nd group served asonly lithiatic control as ethylene glycol (1%) in drinking water. 3rd group Standard drug was given for 14 days (From 15th - 28th day). 4th&5thgroup received KadalikandaKshara(Test drug) at doses of 22.5mg/kg (Therapeutic Equivalent dose - TED), 90mg/kg (Therapeutic Equivalent dose×4 - TED×4) respectively. After 28 days blood & urine samples collected and analyzed for blood and urine parameters. The kidneys were removed sectioned for histopathological examination. The experimental data were expressed as Mean ± SEM of meanand analyzed by one way analysis of variance followed by Dunnett’s multiple “t” test as post hoc test was considered statistically significant. The rats treated with Test drug in both TEDand TED×4 groups has shown significant effect by increasing the volume of urine and elevating pH of urine& has shown very significant reduction in serum uric acid. Histopathology of kidney sections in Group 4 & 5 showed less tissue damage.KadalikandaKsharahas protective effect in urolithiasis.
Authors and Affiliations
C H Arun, Gazala Hussain, Ravi Mundugaru, Ganti Y Basavaraj
Keywords
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- EP ID EP630690
- DOI 10.7897/2277-4572.07176
- Views 38
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