Acute and Subacute Toxicity Study of the Combination of Aqueous Extracts of the Trunk Bark of Musanga cecropioides R. Br. (Cecropiaceae) and the Fruits of Combretum micranthum G. Don (Combretaceae)
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 9
Abstract
The main objective of the work was to evaluate the acute and subacute toxicities of the combinated of aqueous extracts of the bark trunk of Musanga cecropioides and the fruit of Combretum micranthum. The respective extraction yields of 12% and 3.6% were obtained for Combretum micranthum and Musanga cecropioides. Tests of alkaloids, sterols, terpenes, phenols, flavonoids, saponins, coumarins, reducing sugars, tannins were positive with at least one solvent while those of anthraquinones and anthocyanins were negative, with all solvents whatever the species considered. At the end of the fourteen days of study of the acute toxicity, no abnormality of the studied parameters was observed, except for the aggressiveness of the rats, during the first five days. Most parameters varied in different groups during the subacute toxicity study. The values of blood biochemical and hematological parameters of the rats fluctuated sometimes. The study pharmacological activities in vitro and in vivo would allow the development of medicinal products based on these medicinal plants.
Authors and Affiliations
Dibong Siegfried Didier, Etame Loe Gisèle, Tankeu Séverin Elisée, Okalla Ebongue Cécile, Yinyang Jacques, Boudjeka Vanessa, Nda Meffo Jean Pierre, Ngouondjou Fotze Téclaire, Ngene Jean Pierre, Ngoule Charles Christian
Keywords
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