Acute myeloid leukemia/ transient abnormal myelopoeisis masquerading as sepsis in a neonate with down syndrome
Journal Title: IP International Journal of Medical Paediatrics and Oncology - Year 2017, Vol 3, Issue 1
Abstract
A term 7 day old girl with phenotype of Down syndrome presented with irritability, poor feeding and respiratory distress for one day. She had echymotic patches on trunk and arm, moderate hepato-splenomegaly, swollen cyanosed cold right forearm. Neonatal sepsis was suspected but sepsis screen was negative. Peripheral blood smear revealed marked leucocytosis with 70% myeloblast cells, thrombocytopenia and normal erythrocyte count. Bone marrow had 48% myeloblasts. Differential diagnosis of transient abnormal myelopoiesis (with life threatening symptoms) and congenital leukemia were kept. We chose to report this case as it highlights the association between commonest chromosomal anomaly- Down syndrome and various hematological anomalies.
Authors and Affiliations
Naved Akter, Veenu Agarwal, Prachi Kumar
Keywords
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- EP ID EP300706
- DOI 10.18231/2455-6793.2017.0012
- Views 103
- Downloads 0
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