Acute secondary angle closure glaucoma following topiramate
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 6
Abstract
Use of topiramate is associated with a rare syndrome which includes acute myopia along with secondary angle closure glaucoma. It occurs within a month of initiation of therapy. Exact incidence of this syndrome is not known however glaucoma was diagnosed in 0.36%, 0.05% and 0.66% of the study cohort during the first month,second to third month, and fourth to twelfth month in a population based study8. Topiramate is an antiepileptic drug which is used as an anti migraine drug also. A patient on anti migraine therapy with topiramate was referred to our department by the neurologist. At the time of presentation she had high myopia of -7 dioptres in both eyes with raised intraocular tension of 42.1mmhg in right eye and 38.8mmhg in the left eye. Patient responded very well to antiglaucoma medications-systemic-carbonic anhydrase inhibitors, hyperosmotic agents and topical drops. Failure to recognize the ocular side effects and to institute treatment as soon as they manifest may lead to permanent damage to vision.
Authors and Affiliations
A Ghosh, AK Thakkar, RYS Yadav, Shikha Singh, Amit Patel
Keywords
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