ADAPTIVE METHODOLOGY FOR THERMOELECTRIC CHARACTERISTICS CALCULATION OF MYOCARDIAL TISSUE ZONES FROM DIFFERENT ANATOMICAL HUMAN HEART
Journal Title: Вісник Кременчуцького національного університету імені Михайла Остроградського - Year 2017, Vol 1, Issue 104
Abstract
Purpose. To develop adaptive methodology of calculation of myocardial tissue thermoelectric characteristics based on the analysis of heart tissue individual electrical and thermal parameters response to the impact of radiofrequency current, by solving the inverse problem of thermodynamics, that will perform calculations these values for each аpplication point of radiofrequency ablation (RFA) for each patient during catheter procedures in the operating. Using them for myocardium simulation will improve the accuracy of catheter RFA model, their safety and efficacy in clinical practice. Methodology. Analysis has been performed on statistically significant clinical material, covering 1358 points of RFA for the five areas of 83 patients’ hearts . In the process of doing the research the latest specialized high-tech medical equipment has been applied. In the basis of calculation characteristics of myocardial tissue response for RF exposure (current, output power and average power transition temperature in the contact area) have been defined that were recorded on the LabSystem Pro (Bard, USA) electrophysiological station during procedure and characterized electrical and thermal environmental conditions of interaction in different anatomical zone of the heart. Results. Analysis of the clinical database, using numerical methods of its processing, has allowed to quantify biophysical characteristics of the human heart. It has been proposed an original technique of obtaining and interpreting clinical and electrophysical data in real time to calculate the thermoelectric characteristics of the myocardium according to the opinion of heart tissue to effect RFA by solving the inverse problem of thermodynamics, with application of fundamental physical laws of resistive heating and temperature fields distribution in the thickness of the myocardium, taking into account heat transfer and convection. For the first time, there have been determined the thermoelectric characteristics of myocardial tissue zones of different anatomical human heart in which the standard RFA of pathological excitation sources is carried, namely: electrical conductivity, σ = 0,205-0,266 Cm/m; thermal conductivity coefficient, k = 0.523-0,605 W/K∙m; thermal transfer coefficients, h = 435-504 W/K∙m2; heat capacity, c = 1981-2293 J/K∙kg, the degree of capillary perfusion, w = 104,281∙10-6-120,691∙10-6 m3/m3/s; the linear velocity of blood in the electrode space, u = 0,10698-0,196577 m/s. Practical value. The regularities of thermal impact on myocardial tissue of RFA allow to research substantiate prognostic criteria for efficacy and safety of arrhythmogenic sources ablation in different anatomical areas of the heart.
Authors and Affiliations
М. Sychyk, V. Maksymenko, О. Lafeta
Keywords
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