Additive interaction of levetiracetam with lamotrigine in the mouse 6 Hz psychomotor seizure model – an isobolographic analysis
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 1
Abstract
The aim of this study was to characterize the anticonvulsant effects of levetiracetam (LEV) in combination with lamotrigine (LTG – a second-generation antiepileptic drug), in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel dose-response relationship curves (DRRCs) was used to characterize the consequent anticonvulsant interactions between the drug combinations. Results indicated that LEV administered singly was associated with a DRRC that was parallel to that for LTG. With isobolography for parallel DRRCs, the combination of LEV with LTG at three fixed-ratios of 1:3, 1:1 and 3:1 exerted additive interaction. LEV combined with LTG exerted additive interaction in the mouse 6 Hz psychomotor seizure model.
Authors and Affiliations
Jarogniew Łuszczki, Aleksandra Wlaź, Ewa Marzęda, Dariusz Durmowicz, Magdalena Florek-Łuszczki
Keywords
Related Articles
- EP ID EP100401
- DOI -
- Views 115
- Downloads 0
The influence of excipients on dissolution of caffeine from granules
Four formulas of granules with caffeine were chosen to examine the influence of excipients on dissolution profiles of active substance from this drug form. The formula I: caffeine 1.0 parts, potato starch 69,3 parts, lac...
Blood serum vitamin D status evaluated in healthy people
The purpose of the study was to evaluate the status of vitamin D in healthy subjects. Vitamin D level was determined on the basis of blood serum 25(OH)D concentrations, taking into account the time of blood collection an...
Selected caries diagnostic methods
Standard caries diagnostic methods include a visual tactile method, as well as several radiographic methods. The former is a subjective method, while bitewing radiographs and digital radiographs (radiovisiography) enable...
Biochemical parameters of metabolic syndrome in type 2 diabetes patients: retrospective study
Metabolic syndrome is one of the most important problems of public health in developed societies. A constant interest in this issue is caused by a wide spread of this problem and the lack of uniform diagnostic criteria....
Eudragit FS 30D as a potential polymer for use in the technology of preparing matrix tablets contain metronidazole – an experimental and mathematical modeling study
The aim of this study was to examine the usefulness of a pH-dependent copolymer - Eudragit FS - for employment in the technology of preparing modified release metronidazole matrix tablets. In addition, in our work, Eudra...