Additive interaction of levetiracetam with lamotrigine in the mouse 6 Hz psychomotor seizure model – an isobolographic analysis
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 1
Abstract
The aim of this study was to characterize the anticonvulsant effects of levetiracetam (LEV) in combination with lamotrigine (LTG – a second-generation antiepileptic drug), in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel dose-response relationship curves (DRRCs) was used to characterize the consequent anticonvulsant interactions between the drug combinations. Results indicated that LEV administered singly was associated with a DRRC that was parallel to that for LTG. With isobolography for parallel DRRCs, the combination of LEV with LTG at three fixed-ratios of 1:3, 1:1 and 3:1 exerted additive interaction. LEV combined with LTG exerted additive interaction in the mouse 6 Hz psychomotor seizure model.
Authors and Affiliations
Jarogniew Łuszczki, Aleksandra Wlaź, Ewa Marzęda, Dariusz Durmowicz, Magdalena Florek-Łuszczki
Keywords
Related Articles
- EP ID EP100401
- DOI -
- Views 119
- Downloads 0
Prevalence of viruses HBV, HCV and HIV in blood donors at the Regional Centre of Blood Donation and Blood Treatment in Poznan in the years 2008-2010
Currently we may observe increasing demand for blood and its components as well as blood derivatives. Technological progress in viral diagnostics and the use of Good Manufacturing Practice (GMP) rendered the blood safety...
Doxorubicin induces delayed heart and liver mitochondrial depolarisation
The effect of repeated administration of doxorubicin (DOX) on heart and liver morphology, mitochondrial function and redox equilibrium was investigated in rats, contributing in explanation of delayed cardiomyopathy. Male...
Therapeutic management of an injury of the upper incisor within complete root formation
A 9.5 year-old patient, following an accident, suffered a comminuted lateral fracture of the root of tooth 21 at the neck level. The treatment consisted of immobilizing and maintaining tooth vitality. The presented case...
Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats
This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol adminis...
Epidemiology, diagnosis and pharmacotherapy of head injuries in children treated in the Children's Clinical Hospital in Lublin
Head injuries are one of the most common injuries in children. This work is a study of the causes and consequences of such injuries in children, and in so doing, the effects of age and seasons on the injury formation in...