Influence of the dissolution medium type on the release of diclofenac sodium and papaverine hydrochloride from granules and tablets
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 1
Abstract
The release studies of diclofenac sodium (DIC) and papaverine hydrochloride (PAP) from composed granules and tablets into the dissolution media at different pH using the flow-through cell apparatus were carried out. The solubilities of these active substances vary and depend on the pH of a dissolution medium which confirmed the outcomes of the release studies on granules and tablets containing only one substance DIC or PAP. The most effective dissolution medium for the carried out release study of DIC and PAP from composed solid dosage form as granules or tablets was citrate buffer at pH 6.5.
Authors and Affiliations
Regina Kasperek, Magdalena Naleśniak, Karol Iwaniak, Ewa Poleszak
Keywords
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