Dissolution of lithium carbonate from three types extended-release capsules in paddle, basket and flow-through apparatus
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2012, Vol 25, Issue 2
Abstract
Current Issues in Pharmacy and Medical Sciences Vol. 25, No. 2, Pages 164-167 Three types of 24-h extended-release multiparticulate capsules containing a dose of 480-504 mg lithium carbonate in a form of either pellets or 2 mm minitablets or 6 mm tablets were prepared. Dissolutions tests were performed using three different pharmacopoeial apparatus: basket, paddle and flow-through apparatus. Only capsules filled with pellets showed the same dissolution profiles, irrespective of the apparatus used in the study. In the case of two other formulations, the slowest dissolution occurred in the flow-through apparatus. The largest difference between release profiles from different apparatus was observed for the capsule filled with 6 mm tablets. The observations may indicate that probability of good reproducibility of dissolution profiles obtained in different test conditions, including change of apparatus, is related to either size or a number of the units in a capsule.
Authors and Affiliations
Malgorzata Sznitowska, Pawel Pietkiewicz, Agnieszka Dorosz, Jerzy Lukasiak, An Vermeire, Jean Remon
Keywords
Related Articles
- EP ID EP137467
- DOI -
- Views 104
- Downloads 0
Dissolution of lithium carbonate from three types extended-release capsules in paddle, basket and flow-through apparatus
Current Issues in Pharmacy and Medical Sciences Vol. 25, No. 2, Pages 164-167 Three types of 24-h extended-release multiparticulate capsules containing a dose of 480-504 mg lithium carbonate in a form of either pellets...
Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis
This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swis...
The international normalized ratio (INR) as seen in a population of patients with atrial fibrillation and cerebral infarction undergoing long-term treatment with vitamin K antagonists
It is estimated that nearly 20% of all cerebral infarctions in the total population are the result of a complication of atrial fibrillation (AF). While oral anticoagulation with vitamin K antagonists (AVKs) substantially...
The influence of excipients on dissolution of caffeine from granules
Four formulas of granules with caffeine were chosen to examine the influence of excipients on dissolution profiles of active substance from this drug form. The formula I: caffeine 1.0 parts, potato starch 69,3 parts, lac...
An alternative synthesis of Azilsartan: an angiotensin II receptor blocker
This paper provides a description of an alternative, novel and commercially viable process which has been developed for the preparation of Azilsartan, a pro-drug of Azilsartan medoxomil, an angiotensin II receptor blocke...