An alternative synthesis of Azilsartan: an angiotensin II receptor blocker
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2015, Vol 28, Issue 2
Abstract
This paper provides a description of an alternative, novel and commercially viable process which has been developed for the preparation of Azilsartan, a pro-drug of Azilsartan medoxomil, an angiotensin II receptor blocker. The present work also provides a primary account of the synthesis and characterization of the novel intermediates (6, 7 & 10) of Azilsartan, with their spectral data.
Gastrointestinal hemorrhage in a 21-month-old girl in the course of lymphonodular hyperplasia (LNH). Case report
Gastrointestinal hemorrhage is an emergency condition requiring immediate diagnostics. The case of a 21-month-old girl is presented with massive bleeding from the lower gastrointestinal tract in the course of lymphonodu...
Dissolution testing of tablets within and beyond expiration date with olanzapine as pharmaceutical ingredient
The expiration date is a guarantee from the manufacturer that a drug product will remain chemically stable - and thus maintain its full potency and safety - prior to that date. Authors of this study have checked whether...
Comparison of visual, impedance spectroscopy and laser fluorescence methods in detecting early carious lesions on occlusal surfaces
The diagnostic management is a very important and integral part of the entire treatment process and has a direct influence on the decision-taking on the choice of the most appropriate form of therapy consistent with curr...
The role of glycosaminoglycans and proteoglycans in atherosclerosis
Numerous studies point out to the role of glycosaminoglycans (GAG) and proteoglycans (PG) in the pathogenesis of atherosclerosis. Both GAG and PG take part in the formation of tunica intima and tunica media, contribute t...
Multiple sclerosis – causes, risk factors and symptoms of the disease - a literature review
Multiple sclerosis (SM) is a classified chronic disease which leads to disability. Apart from severe cases, persons suffering from SM, live on average, as long as healthy people, however, their everyday life is often con...