Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2015, Vol 28, Issue 3
Abstract
This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes. Type II isobolographic analysis was used to characterize the anticonvulsant interactions between the drugs in combination, for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. The type II isobolographic analysis revealed that the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. We conclude that, as the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 exerted supra-additive (synergistic) interaction in the mouse 6 Hz psychomotor seizure model, this may be considered as particularly favorable combinations in further clinical practice.
Authors and Affiliations
Aleksandra Wlaz, Maria Kondrat-Wrobel, Katarzyna Zaluska, Ewelina Kochman, Anna Rekas, Jarogniew Łuszczki
Keywords
Related Articles
- EP ID EP106724
- DOI 10.1515/cipms-2015-0073
- Views 73
- Downloads 0
Influence of combined treatment with mianserin and simvastatin on selected biochemical serum parameters of liver and kidney function in rats
The aim of the present study was to assess the impact of combined 14-day treatment with mianserin (10 mg/kg) and simvastatin (1 or 10 mg/kg) on selected biochemical liver and kidney parameters in rats (AST and ALT activi...
Multiple sclerosis – causes, risk factors and symptoms of the disease - a literature review
Multiple sclerosis (SM) is a classified chronic disease which leads to disability. Apart from severe cases, persons suffering from SM, live on average, as long as healthy people, however, their everyday life is often con...
Antimicrobial activity of petroleum ether and methanolic extracts from fruits of Seseli devenyense Simonk. and the herb of Peuce
Plants of the Apiaceae family usually contain coumarins. These are used worldwide in traditional medicine, as well as in modern therapeutics. The aim of our study was to determine the antimicrobial activity of four extra...
The survival of dental implants with different implant-abutment connection systems
The aim of the study was to evaluate the survival of implants with different implant-abutment connection systems, in patients who had two kinds of implants implanted. In total, 240 implants were implanted – 91 implants w...
Physical and chemical properties of cosmetic cream made of ingredients obtained from Juglans regia L.
The aim of the study was obtaining the cosmetic cream containing walnut oil, defatted walnut seeds and gelling agents like beeswax and witepsol. The walnut oil and defatted walnut seeds were received by extraction method...