Influence of combined treatment with mianserin and simvastatin on selected biochemical serum parameters of liver and kidney function in rats
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 3
Abstract
The aim of the present study was to assess the impact of combined 14-day treatment with mianserin (10 mg/kg) and simvastatin (1 or 10 mg/kg) on selected biochemical liver and kidney parameters in rats (AST and ALT activities and the concentrations of AFP, total protein, urea, creatinine and ß2-M). The results showed the increase in both transaminases activities, creatinine concentration and the decrease of AFP, total protein and ß2-M concentrations. The results indicate that 14-day combined administration of mianserin with simvastatin negatively affects the liver functioning. The observed changes in kidney biochemical parameters may suggest a risk of renal dysfunction during long-term combined treatment with these drugs.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP105400
- DOI -
- Views 64
- Downloads 0
The circumstances of diagnosis of occult haemophilia B in a patient with severe maxillofacial injuries
The most common haemostasis disorders are haemophilia A, B and von Willebrand disease. Symptoms of congenital bleeding diathesis can be observed in early childhood, and are easy to recognize. Medical literature describes...
Determination of caffeic acid in root and rhizome of Black cohosh (Cimicifuga racemosa (L.) Nutt).
Cimicifuga racemosa, is a plant with a diverse and long history of medicinal use. Caffeic acid, bioactive compound, which often occurs with other polyphenols can influence the biological activity of this plant. The aim o...
Influence of astemizole, an H1 receptor antagonist, on the locomotors activity of carbamazepine and valproate in mice
In the present study, we examined the influence of the second generation H1 receptor antagonist, astemizole, co-administered with carbamazepine and valproate on the exploratory and spontaneous activities in mice. Locomot...
Designing primers potentially specific to Entamoeba gingivalis genes
Entamoeba gingivalis normally exists in the human oral cavity, namely in the gums, and brings about some specific diseases. However, it can also trigger some more serious illnesses. Among these are infections of the geni...
Serum leptin concentration in patients with type 2 diabetes
With the increasing importance of early type 2 diabetes (DM2) and obesity detection, it is useful to reevaluate leptin role in these conditions. Our study aimed at investigating circulating leptin concentrations in a gro...