ADENOSINE DEAMINASE: A TARGET ENZYME IN DIFFERENT PATHOLOGIES – A REVIEW

Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 8

Abstract

Adenosine is an anti-inflammatory agent, involved in the cellular energy and purine metabolism. Its derivatives of nucleotide and nucleoside nature have both the therapeutic significance in the treatment of immune, cardio and neurodegenerative disorders, and sometimes, can posses the toxic action on the cells and mammalian tissue. Adenosine deaminase is one of the enzymes participating in inactivation of the adenosine derivatives both in the intra- and intercellular medium. Therefore, the search for the regulators of activity of adenosine deaminase is a very important task of modern pharmacology. The solution of this task demands the knowledge on the catalytic peculiarities, active site structure, interaction with the substrates and with the probable inhibitors of the enzyme. This work reviews the information on the indicated fields available to date.

Authors and Affiliations

Dr. Alvard Antonyan

Keywords

Related Articles

GREEN BIOTECHNOLOGY: A REVIEW

Green biotechnology manages the utilization of earth amicable arrangements as a contrasting option to customary agribusiness, cultivation, and creature rearing procedures. A case is the outlining of transgenic plants tha...

UPDATE ON KEY FACTORS FOR ACHIEVING OSSEOINTEGRATION

During the past two decades, dental implants have been used extensively to achieve osseointergration for prosthetic rehabilitation of edentulism. For this, a surgical procedure is performed on patient to insert a foreign...

THE ABUNDANCE OF MUD CRAB (Scylla serrata FORSKAL, 1775) IN SUNGAI PISANG MANGROVE FOREST, PADANG CITY, WEST SUMATRA, INDONESIA

Mud Crab (Scylla serrata Forskal 1775) is an animal that live in the mangrove forest region. This study aims to know and to analyze abundance the population of mud crab (Scylla serrata Forskal 1775) at the Sungai Pisang...

JALAUKA (LEECH)…THE PARA SURGICAL INSTRUMENT

Panchkarma is globally accepted and famous branch of Indian system of medicines i.e. Ayurveda. Raktamokshan has been described as a part of shodhan by Sushruta. Jalaukavacharan karma is the part of Raktamokshana .In pres...

PRAKṚTI AS A RISK FACTOR IN MEDOROGA (DYSLIPIDEMIA): A NIDĀNĀTMAKA STUDY INCORPORATING WHO STEPS APPROACH

Context: Prakṛti determines the response of an individual to environmental factors, drugs and susceptibility to diseases making it one of the earliest known concepts of predictive, preventive and personalized medicine. C...

Download PDF file
  • EP ID EP649527
  • DOI -
  • Views 170
  • Downloads 0

How To Cite

Dr. Alvard Antonyan (2017). ADENOSINE DEAMINASE: A TARGET ENZYME IN DIFFERENT PATHOLOGIES – A REVIEW. World Journal of Pharmaceutical and life sciences, 3(8), 6-18. https://europub.co.uk/articles/-A-649527