Advanced Central Effects of Yohimbine on the Cognitive Function, Psychomotor Performance Task and Working Memory: A Randomized Controlled Clinical Trial Study
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 5, Issue 5
Abstract
Systemic administration of yohimbine lead to powerful anxiety-promoting effects and facilitated long-term performances, due to α2- adrenergic receptor action , while its effect on the extinction of reward-related memories are probabilistically independent of their effects on α2- adrenergic receptors. So the objective of presenting study was to evaluate the enhancement effects of yohimbine on psychomotor performance and working memory in normal young healthy volunteers. Twenty subjects (10 females: 10 males) randomly chosen by medical students. They were healthy, young volunteers aged 21 - 23 years were incorporated in the study while those with proof of any disease were excluded. The participants were permitted to practice on both the psychomotor tester and the n-back task (working memory test) to obtain familiarity with those tests before the commencement of the trial. Yohimbine significantly improve human psychomotor reaction time, and critical flicker fusion threshold significantly (p<0.05) also it improve accuracy rates in both 1-Back and 2-Back significantly (p<0.05) but produced insignificant effects on 3-Back (p>0.05). In conclusion yohimbine improve psychomotor performances and working memory, thus advance the cognitive function via activation of noradrenergic system.
Authors and Affiliations
Hayder M. Al-Kuraishy, Ali I. Al-Gareeb
Keywords
Related Articles
- EP ID EP344369
- DOI 10.9734/BJPR/2015/15255
- Views 61
- Downloads 0
Assessment of Anti-atopic Dermatitis Activity of Oroxylum indicum Extract Incorporated Cream
Aims: The search for plant-based treatments against atopic dermatitis (AD), a relapsing dermatological condition with high prevalence in tropical regions, has always been attracting special attention. Among many folk rem...
Pre-clinical Evaluation of the Hypotensive and Anti Atherogenic Activity of Hydroethanolic Extract of Eribroma oblongum (Malvaceae) Stem Bark on Wistar Rats Models
Aims: The stem bark of Eribroma oblongum (Malvaceae) is used in traditional Cameroonian medicine to treat various metabolic illnesses including the management of hypertension without scientific evidence to how relief is...
Effect of Aqueous and Ethanol Leaf Extracts of Landolphia dulcis on Haematology and Histopathology of Swiss Albino Mice
Aims: To evaluate toxicological effect of aqueous and ethanol leaf extracts of Landolphia dulcis on haematology, liver and kidney physiological changes in mice. Study Design: In-vivo. Place and Duration of Study: Microb...
Use of Hydrazine Carboxamide-2-[(2-Hydroxy-1- Naphthalenyl) Methylene] as an Analytical Reagent for the Extractive Spectrophotometric Determination of U(Vi)
Extraction and spectrophotometric determination of Uranium (VI) was carried out using Hydrazine Carboxamide-2-[(2-Hydroxy-1-Naphthalenyl) Methylene] as an analytical reagent. A reddish brown coloured complex is formed at...
UV Spectrophotometric Method for the Simultaneous Determination of Desloratidine and Pseudoephedrine HCl in Combined Dosage Form
Aims: UV Spectrophotometric Method for the Simultaneous Determination of Desloratidine and Pseudoephedrine HCl in combined Dosage form. Study Design: A simple, rapid and specific UV spectroscopic method with good sensiti...