Advanced Hepatocellular Carcinoma in A Scottish Population – Current Experience and the Future
Journal Title: Current Trends in Gastroenterology and Hepatology - Year 2018, Vol 1, Issue 3
Abstract
Sorafenib is the current first line standard of care in patients with advanced hepatocellular carcinoma (HCC). Several other drugs are emerging as efficacious agents in this setting. This article will outline our current real-world experience with sorafenib in a Scottish population as well as discuss the evidence behind new potential therapies. Hepatocellular carcinoma (HCC) is the fifth most common cancer affecting patients worldwide and accounts for 2% of cancer cases in the United Kingdom [1,2]. Incidence is rising and it is associated with several known risk factors including heavy alcohol consumption, non-alcoholic steatohepatitis and chronic hepatitis B and C infection [3,4]. If detected at an early stage, HCC is potentially curable. Unfortunately, many patients are diagnosed at an advanced stage (according to the Barcelona Clinic Liver Cancer criteria) and treatment is therefore palliative focusing on prolonging survival and improving symptom burden. In the advanced setting, sorafenib is recommended as first line option in patients who cannot benefit from resection, transplantation, ablation or transarterial chemoembolization (TACE), and who still have preserved liver function [5]. Sorafenib is the only drug that has shown a significant survival benefit in the last decade. It is a multi-kinase inhibitor with particular action against VEGFR2, PDGFR, FGFR1, Raf-1, B-Raf and c-Kit receptors [6].
Authors and Affiliations
Baxter MA, Peters AL, Graham J
Keywords
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- EP ID EP570002
- DOI 10.32474/CTGH.2018.01.000112
- Views 73
- Downloads 0
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