Eradication Failure of Helicobacter Pylori Among Children’s Population
Journal Title: Current Trends in Gastroenterology and Hepatology - Year 2018, Vol 1, Issue 5
Abstract
Helicobacter pylori (H. pylori) is a Gram-negative bacterium responsible for the development of gastritis that may further progress to more severe conditions, peptic ulcer disease and gastric cancer [1,2]. H. pylori have infected from 80% to 90% of the population in Russia [3]. Despite the ongoing discussion on which H. pylori infected patients should be treated up till full eradication of the infection, eradication depending on the prevalence of strains resistant to antibacterial preparations using for treatment [4]. Currently, the eradication of H. pylori is managed by the use of a triple therapy, involving the co-administration of two antibiotics and a proton pump inhibitor or bismuth during ten or fourteen days [4,5]. The resistance of H. pylori to antibiotic is a key problem to all bacteria, gaining importance if leads to treatment failure [6]. Even with the current most effective treatment regimens, about 10% to 20% of patients will fail to eradicate Helicobacter pylori infection [7]. The study of eradication failure in Russian Federation was not found, more over in the Khanty-Mansiysk Autonomous Okrug - Ugra was not found as well. The most prescribed preparations are the Macrolides, Fluoroquinolones, Amoxicillin, Nitroimidazoles, Tetracycline among others. At the same time among the antibiotics applied in schemes of eradication H. pylori of the first line, most the problem of resistance is particularly actually to a Clarithromycin [8]. According to work of De Francesco and others in the world population the following indicators of resistance of H. pylori to antibiotics in schemes of eradication therapy Table 1 are noted [9].
Authors and Affiliations
Poul Minochkine, Kirill Telitsyn
Keywords
Related Articles
- EP ID EP570958
- DOI 10.32474/CTGH.2018.01.000121
- Views 54
- Downloads 0
Successful Endoscopic Treatment of Refractory Postoperative Duodenocutaneous Fistula using Fibrin Sealant
Iatrogenic, postoperative enteroatmospheric fistulas remain difficult to manage but common problem after gastrointestinal surgery. Surgical revision, after failure of conservative treatment is not only partially efficien...
Fungal Infections in Gastroenterology
Fungal infections are increasing in gastroenterology. Cirrhotic patients, liver transplantation recipients, and patients with inflammatory bowel disease (IBD) are vulnerable to these infections. The origin of these funga...
Hispanic Ethnicity is Associated with Milder Disease Severity in Crohn’s Disease but not Ulcerative Colitis
Background: The incidence of inflammatory bowel disease (IBD) is rising among minority patients; however, few studies have examined racial/ethnic disparities in epidemiology, disease severity, and treatment course. Aim:...
The Current Approach to the Hepatocellular Carcinoma; A Mini Review of Etiology, Prognosis and Treatment
Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and is one of the major causes of cancerrelated deaths. HCC is reported to be the second most fatal malignancy. The major risk factors for HCC...
Rifaximin for Treatment of Small Bowel Bacterial Overgrowth
Small intestinal bacterial overgrowth (SIBO) is often secondary to intestinal dysmotility and several other predisposing conditions. Treatment of SIBO typically includes antibiotics and treatment of underlying etiology....