Eradication Failure of Helicobacter Pylori Among Children’s Population
Journal Title: Current Trends in Gastroenterology and Hepatology - Year 2018, Vol 1, Issue 5
Abstract
Helicobacter pylori (H. pylori) is a Gram-negative bacterium responsible for the development of gastritis that may further progress to more severe conditions, peptic ulcer disease and gastric cancer [1,2]. H. pylori have infected from 80% to 90% of the population in Russia [3]. Despite the ongoing discussion on which H. pylori infected patients should be treated up till full eradication of the infection, eradication depending on the prevalence of strains resistant to antibacterial preparations using for treatment [4]. Currently, the eradication of H. pylori is managed by the use of a triple therapy, involving the co-administration of two antibiotics and a proton pump inhibitor or bismuth during ten or fourteen days [4,5]. The resistance of H. pylori to antibiotic is a key problem to all bacteria, gaining importance if leads to treatment failure [6]. Even with the current most effective treatment regimens, about 10% to 20% of patients will fail to eradicate Helicobacter pylori infection [7]. The study of eradication failure in Russian Federation was not found, more over in the Khanty-Mansiysk Autonomous Okrug - Ugra was not found as well. The most prescribed preparations are the Macrolides, Fluoroquinolones, Amoxicillin, Nitroimidazoles, Tetracycline among others. At the same time among the antibiotics applied in schemes of eradication H. pylori of the first line, most the problem of resistance is particularly actually to a Clarithromycin [8]. According to work of De Francesco and others in the world population the following indicators of resistance of H. pylori to antibiotics in schemes of eradication therapy Table 1 are noted [9].
Authors and Affiliations
Poul Minochkine, Kirill Telitsyn
Keywords
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- EP ID EP570958
- DOI 10.32474/CTGH.2018.01.000121
- Views 53
- Downloads 0
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