Hispanic Ethnicity is Associated with Milder Disease Severity in Crohn’s Disease but not Ulcerative Colitis
Journal Title: Current Trends in Gastroenterology and Hepatology - Year 2019, Vol 2, Issue 2
Abstract
Background: The incidence of inflammatory bowel disease (IBD) is rising among minority patients; however, few studies have examined racial/ethnic disparities in epidemiology, disease severity, and treatment course. Aim: To characterize differences in IBD disease severity and outcomes among IBD patients from minority communities. Methods: A cohort of adult patients with IBD was followed from January 2007- December 2012 in a large urban safety-net hospital. Fisher exact and Mann-Whitney rank sum tests were used to compare disease phenotype, severity, need for anti-TNF therapy, receipt of IBD-related surgery, and hospitalizations. Results: We identified 291 adult IBD patients; 148 with Crohn’s Disease (CD), 143 with ulcerative colitis (UC). Our cohort was racially diverse with 32% Caucasian, 37% Black, 28% Hispanic, and 2% Asian. 54% were male and the median age of the cohort was 44 years. Hispanic patients had a more benign disease course characterized by less IBD-related surgeries (mean 0.4 vs. 1.1, p=0.001), less hospitalizations (mean 2.1 vs. 2.9, p=0.04), and lower need for anti-TNF therapy (27% vs. 39%, p=0.05) when compared to non-Hispanic patients. On subgroup analysis, these differences were noted particularly among those with CD but not UC. Hispanic UC patients had a similar number of IBD-related surgeries (p=0.16) and hospitalizations (p=0.62), whereas Hispanic CD patients had less IBD-related surgeries (mean 0.8 vs. 1.8, p=0.01), less hospitalizations (mean 2.4 vs. 3.8, p=0.05), and lower need for anti-TNF (38% vs. 57%, p=0.09). Conclusion: Hispanic ethnicity is associated with lower disease severity in CD but not associated with disease severity in UC.
Authors and Affiliations
Christie Choi, Amit Singal, Kunjali Padhya, Avegail Flores, Ezra Burstein, Tasneem Ahmed
Keywords
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- EP ID EP573133
- DOI 10.32474/CTGH.2019.02.000132
- Views 67
- Downloads 0
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