Advancements in understanding the regulatory mechanism of B-cell immune activation associated with adenotonsillar hypertrophy
Journal Title: Biomedical Transformation - Year 2024, Vol 5, Issue 2
Abstract
B cells play a crucial role in recognizing external antigens through their surface B cell receptor (BCR), essential for generating protective antibodies and immune memory. Regulation of B cell immune activation is closely linked to various upper respiratory tract diseases. Adenoid hypertrophy (ATH), a common childhood condition, is characterized by lymphoid follicular hyperplasia, yet its exact mechanisms remain elusive. This review consolidates research on BCR trophic signaling that sustains B cell viability in resting state. It clarifies the regulatory mechanisms governing B cell immune activation and the establishment of rapid, effective immune memory, with a specific focus on early molecular activation events and the pivotal role of mIgG-tail in memory antibody responses. Dysregulation of B cell activation processes can disrupt immune balance, potentially precipitating disease. This synthesis explores the connection between regulation of B cell activation and ATH pathogenesis, examining the potential impacts of signaling pathway dysregulation or mutations on ATH. The review aims to enhance understanding of the disease mechanisms underlying ATH, with the goal of identifying new diagnostic and therapeutic targets for this condition.
Authors and Affiliations
Chen Wenjing, Gao Ruiyu, Huang Jingwen, Ye Jingying, Liu Wanli
Keywords
Related Articles
- EP ID EP766002
- DOI 10.12287/j.issn.2096-8965.20240210
- Views 9
- Downloads 0
Risk factors, pathogenic mechanisms and treatment progress of coronary in-stent restenosis
Coronary artery disease (CAD) has become one of the leading causes of death worldwide. Percutaneous coronary intervention (PCI) is one of the main treatments for CAD. Coronary in-stent restenosis (ISR) refers to the re-n...
Research progress on effect of nutritional factors on precocious puberty in children
Precocious puberty refers to the premature onset of pubertal development in children before a specific age threshold, which can adversely affect their growth and development, as well as their health in adulthood. Nutriti...
Application and progress of tissue engineering technology in vaginal reconstruction
Vaginal defects cause immense physical and psychological stress to patients. Traditional vaginal reconstruction methods can partially restore physiological function but are often associated with long treatment periods an...
Progress and applications of epidemiological research on myopia prevention and control for children and adolescents in the context of interdisciplinary research
Myopia has become a major global public health concern, with its prevalence increasing significantly among children and adolescents. Epidemiological research has played a crucial role in myopia prevention and control, bu...
Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Its progression is closely associated with metal metabolism abnormalities and mitochondrial quality deteriorati...