Advances in the diagnosis and treatment of TFE3 fusion gene-associated renal cell carcinoma
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 6
Abstract
Transcription factor E3 (TFE3) is a member of the bHLH transcription factor family. TFE3 fusion geneassociated renal carcinoma is a rare renal malignant tumor driven by the fusion of TFE3 and other genes. It tends to occur in children and adolescents, and is rare in adults, but more prone to lymph node and distant organ metastasis. The screening is usually made by immunohistochemical staining, and the diagnosis is confirmed by FISH detection of TFE3 split gene. Surgery is the first choice of treatment for patients who are inoperable or have postoperative recurrence. At present, there is no standard systematic treatment plan, and targeted therapy and immunotherapy are still in the clinical research stage. This paper reviews TFE3 fusion gene renal cell carcinoma and its diagnosis, treatment and related research progress, in order to provide help for further research on this type of renal cell carcinoma in the future.
Authors and Affiliations
DOU Qiongyi, AI Liping, BAI Yinmiao, ZHANG Hongmei
Keywords
Related Articles
- EP ID EP727737
- DOI -
- Views 8
- Downloads 0
Achievements and prospects of biological research of intervertebral disc degeneration in China
Intervertebral disc degeneration (IDD) represents the key pathological foundation of degenerative spinal diseases, which often results in low back pain, spinal stenosis and finally leads to mobility limitation and loss...
Abnormal spectrum analysis of ophthalmological elimination in medical selection of students in teenagers aviation schools in Hebei Province
Objective To explore the characteristics and regional differences of the abnormal spectrum of ophthalmological elimination in medical selection of students in teenagers aviation schools in Hebei Province, in order to s...
Problems and challenges of heart transplantation and artificial heart in the treatment of end-stage heart failure
The incidence and mortality of heart failure are high, which seriously affects the quality of life and longevity of patients. Allogeneic heart transplantation ( ereinafter referred to as heart transplantation) is an effe...
Advances in understanding the mechanism of cancer from the perspective of ribosomopathies
Ribosomes are one of the widespread and numerous organelles, whose abnormal biogenesis and function can cause ribosomopathies, which are characterized by high cancer predisposition. Studies have shown that the pathophy...
Interference of information processing in spatial visualization
Objective To explore the interference effect of simultaneous processing of different spatial information in spatial visualization, so as to provide reference for pilot psychological selection and training. Methods A sim...