ADVERSE EVENTS OF DRUG TREATMENT IN 547 PEDIATRIC PATIENTS WITH RHEUMATIC AUTOIMMUNE DISEASES: A RETROSPECTIVE COHORT IN A SINGLE CENTER
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 7
Abstract
Introduction: Treatment of autoimmune rheumatic diseases (AIRDs) can cause adverse events (AEs) and the severity depends on different factors. Objectives: To describe the AEs of the medications used in the treatment of AIRDs and to report their severity, associated factors, procedures and the follow-up in patients with juvenile idiopathic arthritis (JIA), juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM). Methods: Retrospective descriptive and analytical study of a cohort of pediatric AIRDs. We evaluated all AEs and the aggravating factors for the AE. A regression logistic model and a multiple regression model of Poisson were set up. Results: 547 patients were included and 951 AEs were observed. MTX was the cause of the most AEs (63.3% of patients), followed by the GCs. Other immunosuppressive medications, biological agents and gammaglobulin also caused AEs. The risk of AEs to MTX and to GCs was higher in patients up to 16 years of age and who received MTX subcutaneously. In addition, the patients with JIA and JDM presented less risk of AEs to GCs than patients with JSLE. In the multiple regression model every additional month of use of GCs led to an increase of 0.5% in the mean of number of AEs. Two patients (0.2%) presented life threatening AEs. Drug withdrawal occurred in 23.9% of cases. Conclusion: This study is unique because it is the largest retrospective study in the literature, which focuses on the AEs for medications used in the treatment of childhood AIRDs in a specialized center.
Authors and Affiliations
Terreri MT
LEVELS OF INTERLEUKIN-17 AND VITAMIN D AND THEIR CORRELATION IN VIRAL HEPATITIS PATIENTS
Background: The interleukin 17 is usually linked to tissue damage in autoimmune disorders and bacterial and fungal infections. In both chronic Hepatitis B and Hepatitis C Virus infections, some reports show a close relat...
EPIDEMIOLOGY AND MORTALITY OF BURNS IN IMAM ALI AND AL-KINDI TEACHING HOSPITAL IN BAGHDAD/ IRAQ
Background: Despite the progress of the health system, burns remained a problem that cannot be solved or find a way to reduce the complications. All these obstacles are caused by poor health management and lack of financ...
THE EFFICACY OF FENTANYL AND FENTANYL PLUS LIDOCAINE IN HYPERTENSION
This trial aimed to evaluate and to compare the efficacy of fentanyl and fentanyl plus lidocaine in hypertension. We conducted a prospective, randomized, doubleblind trial in 40 patients with hypertension in the alkark H...
EXPRESSION OF GASTRIN-17, PEPSINOGEN I AND II AND HELICOBACTER PYLORI IgG IN A SRI LANKAN DYSPEPTIC PATIENT POPULATION USING GASTROPANEL
Objective: This study was aimed to assess the usefulness of Gastropanel assay, an ELISA-based non-invasive diagnostic technique, in diagnosis of H. pylori infection and disease severity in a Sri Lankan population. Method...
MOLECULAR DETECTION OF RPOB GENE FROM ACINETOBACTER BAUMANNII ISOLATED FROM DIFFERENT CLINICAL SOURCES
This study carried out to detection of rpoB gene from Acinetobacter baumannii isolated from different clinical sources in Baghdad governorate. A total (200) clinical samples were collected from different clinical sources...