EFFECT OF PEGANUM HARMALA AQUEOUS EXTRACT ON EXPERIMENTALLY INDUCED DIABETES MELLITUS IN RABBITS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 2
Abstract
Objective: To investigate antidiabetic analysis of Peganum harmala seeds aqueous extract in streptozotocine induced diabetic rabbits by administering oral doses (5 mg/kg body weight). Methods: Experimental diabetes was induced by intraperitoneal injection of streptozotocin (STZ) at a dose of 45 mg/kg body weight per day for 3 days. Adult male rabbits were divided into four groups; normal control, diabetic control, diabetic+ Peganum harmala supplement (5mg /kg b.wt.), and normal+ Peganum harmala supplement (5mg /kg b.wt.) for 14 days. Serum glucose, insulin, triglycerids, cholesterol, urea, creatinine, activities of serum marker enzymes of liver function(AST and ALT) were measured. The oxidative stress was assessed by glutathione-S-transferase (GST) and catalase (CAT) in plasma. Results: The increase in serum glucose, triglycerides, cholesterol, AST and ALT, decreased insulin, plasma GST, CAT, were the salient features recorded in diabetic control rabbits. The Peganum harmala supplements significantly reverted the levels of the studied metabolites and enzymes activities to near normal control values. Conclusions: the current study suggest that aqueous extract of Peganum harmala seeds powder oral doses (5 mg/kg body weight) supplementation may be beneficial for preventing diabetic complications in this animal model.
Authors and Affiliations
Tahani Y. Omar
Keywords
Related Articles
- EP ID EP619171
- DOI -
- Views 121
- Downloads 0
AN IMPERATIVE REVIEW STUDY ON CONCEPT OF OPHTHALMOLOGY IN AYURVEDA IN THE PURVIEW OF RACHANA SHARIR (HUMAN ANATOMY)
Ophthalmology in ayurveda is a branch of a perfect science strictly based upon ayurvedic principles. With the changing concepts of health and disease and shifting scenario of health needs of the present times, there has...
SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL STUDY OF NOVEL AZO-SCHIFF BASE COMPLEXES DERIVED FROM SULFADIAZINE AND 2-(DIETHYLAMINO)ETHYL -4- AMINOBENZOATE
A new series of transtion metal complexes of Co (II), Cur (II), Ni (II) and Cr(III). were prepared from the novelazo-schiff base ligand (LH)(L= 3-chloro-N-(2- diethylamino)ethyl)-4-(((Z)-2-hydroxy-5- ((Z)(-4-(N-(pyrimidi...
IMPACT OF TEENAGE PREGNANCY ON MATERNAL AND NEONATAL OUTCOMES IN BAGHDAD CITY
Background: Adolescent pregnancy is common health problem still found in both developed and developing countries. Adolescent mother face substantially higher maternal and perinatal morbidity and mortality than adult wome...
LOCAL SURVEY FOR AWARENESS OF HYPERACIDITY AND/OR OTHER ASSOCIATED PROBLEMS
Awareness for Hyperacidity and associated problems was judged in a population of Worli area of Mumbai during a medical camp held on March 15, 2017 at the campus of M.A. Podar (Govt.) Hospital, Worli, Mumbai-18. As prepar...
CONTRIBUTION OF UNANI MEDICINE IN MODERN OPHTHALMOLOGY-AN ASSET TO BE PROBED
Ophthalmology is a special branch of modern medicine dealing with the eye ailments has gained special attention in the present scenario of specialization of health services. Unani Medicine is one of the ancient systems o...