Adverse Reactions Due to Directly Observed Treatment Short Course Therapy: An Indian Prospective Study
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Tuberculosis (TB) causes enormous social and economic disruption and hampers nation’s development. DOTS strategy under RNTCP is one of the largest public health programs found to be beneficial against TB. Adverse drug reactions lead to decrease in patient compliance and adherence. Good patient adherence to the treatment regimen is the foundation stone to effective anti-tubercular therapy. Noncompliance is cited as the major problem to the control of the tuberculosis at the level of public health which finally leads to drug resistance in case of TB. Aim and Objectives: To identify the occurrence and pattern of Adverse Drug Reactions (ADRs) associated with anti-tubercular drugs in TB patients under DOTS therapy during Intensive phase of treatment. Materials and methods: A prospective observational study was conducted in 2 randomly selected DOTS centers of Jalandhar. A total of 102 patients of categories I and II who were registered in third quarter of 2014 were selected for study. The follow up period was during the intensive phase of DOTS regimen. All patients on ATT were followed up at the end of 1 week, 1 month and after the completion of intensive phase or if/ when self reporting was done due to adverse drug reactions. Detection and monitoring of adverse drug reaction was done by interviewing patients, consulting with physicians about the patient’s clinical problems, reviewing laboratory test and medical records. The data so collected was entered and analyzed using SPSS 21 software. Results: The Incidence of adverse drug reaction was observed in 20.4% i.e. 21 out of 102 patients. Total number of adverse reactions developed in 21 patients were 31, with most common being GIT system (38.7%), followed by skin problems (29%). History of alcoholism, associated co-morbidities, pulmonary TB and DOTS treatment Category II were found to be significantly associated with occurrence of ADRs. Conclusion: The present study highlighted the importance of developing strategies to ameliorate ADRs both to improve the quality of patient care and to control TB safely. In addition, a proper educational counseling may promote more ADR reporting by patients. These strategies may improve the patient adherence to treatment and therapeutic outcome.
Authors and Affiliations
Gurprit Singh Nanda, Harinder Singh, Bhuwan Sharma, Anjali Arora
Keywords
Related Articles
- EP ID EP417555
- DOI -
- Views 101
- Downloads 0
Prognostic significance of non-enteric blood culture in diabetic foot disease
The diabetic foot is a group of syndromes in which ischemia, neuropathy and infection leads to tissue breakdown resulting in morbidity and possible lower extremity amputation. The diagnosis is based on clinical criteria...
A study of maternal deaths from preeclampsia and eclampsia in a tertiary care centre
Background: Hypertensive disorders of pregnancy (HDPs) affect about 10% of all pregnant women around the world and are an important cause of maternal and perinatal mortality and morbidity. In Asia and Africa, nearly one...
Bacteriological profile of surgical site infections
Background: Surgery has made great advances in last 3 quarters of this century and post-operative wound infection is the most common complication faced by surgeon since the advent of surgery. Aim: To determine the bacter...
Laparoscopic appendicectomy surgery using spinal anesthesia
Laparoscopic abdominal surgery is conventionally done under general anesthesia. Spinal anesthesia is usually preferred in patients where general anesthesia is contraindicated. We have presented here our experience using...
A Study of Clinical Profile and Management of Patients with Chronic Constrictive Pericarditis - Our Experience
Introduction: The constrictive Pericarditis is a disabling condition but has a good prognosis if surgery is undertaken in time. Pericarditis can be seen as an effusive disease or progressive cardiac constriction. Patient...