Agenesis of corpus callosum: genetics, epidemiology and neuroimaging findings
Journal Title: Progress in Health Sciences - Year 2011, Vol 1, Issue 2
Abstract
Agenesis of the corpus callosum (ACC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1:4000 individuals. It is characterized by a partial or complete absence (agenesis) of an area of the brain that connects the two cerebral hemispheres. The cause of ACC is usually not known, but it can be inherited as either an autosomal recessive trait or an X-linked dominant trait. It can also be caused by an infection or injury during the twelfth to the twenty-second week of pregnancy leading to developmental disturbance of the fetal brain. Intrauterine exposure to alcohol can also result in ACC. In some cases mental retardation may result, but intelligence may be only mildly impaired and subtle psychosocial symptoms may be present. Prognosis varies depending on the type of callosal abnormality and associated conditions or syndromes. Online searches of the databases EMBASE, PubMed, and Medline were performed, using the search terms children, corpus callosum, agenesis, absence, genetics, and neuroimaging. In this article, we presented genetics, epidemiology, and neuro-imaging of ACC for the last decade
Authors and Affiliations
E. Gościk, P. Kułak
Keywords
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