AgNOR Staining in Prostatic Carcinoma - Comparative study with Bcl-2 and Gleason Score
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 10
Abstract
Introduction: AgNOR, a synonym for silver stained nucleolar organizing regions (NORs) of DNA located on the short ends of acrocentric chromosomes are emphasized in actively proliferating cells. When compared with immunohistochemistry, AgNOR can give information related to the proliferation status of the tumours as inferred by ki67 other proliferation and apoptotic markers. In this study we compare the AgNOR staining patterns in prostatic carcinoma with the Gleason score and immunohistochemical markers Bcl-2. Methods: The present study was done on 62 cases of Prostatic carcinoma. In this study we compare the AgNOR staining patterns in prostatic carcinoma with Gleason score and immunohistochemical markers Bcl-2.This study will be able to ascertain the efficacy of AgNOR staining as a substitute Bcl-2. Statistical analysis of mAgNOR count with Gleason score and Bcl-2 was done by SPSS software statistics By using Kendalls tau b test. Results: mAgNOR shows statistically significant correlation with Gleason score and insignificant correlation with Bcl-2. Conclusions: Silver staining of Nucleolar organizer regions is a useful method in identifying and grading of prostatic carcinoma. mAgNOR count show positive correlation with Gleason score so, AgNOR staining may substitute the proliferative marker IHC in lab where IHC facility is not available.
Authors and Affiliations
Khethmal P.
Keywords
Related Articles
- EP ID EP489904
- DOI -
- Views 41
- Downloads 0
Anaphylaxis and Human Seminal Plasma Allergy: A Review
Allergy can be defined as a detrimental immune-mediated hypersensitivity response to common environmental substances. The immune processes of allergy usually rely on the production of IgE antibodies specific to common al...
Clinical Study of Rheumatological Manifestations in Type 2 Diabetes Mellitus Patients
Objectives: Type 2 diabetes mellitus is associated with various rheumatological manifestations that are debilitating and affect the quality of life. The present study was conducted to find the prevalence of rheumatologic...
Comparative Study of Invasive Blood Pressure Monitoring in Femoral and Radial Artery and their Correlation with Noninvasive Blood Pressure Monitoring
In critical care units various decisions are taken on the basis of blood pressure recordings, however, non invasive blood pressure and invasive arterial blood pressure recordings often give different values, and the reas...
Profile of Hyponatremia in Patients admitted into Medical ICU
Background: Hyponatremia is a common metabolic disorder in all subsets of patients including critically ill medical patients. Hyponatremia is caused by a diverse set of causes and evaluation at times can be challenging....
A Study of Lung Function Abnormalities in Patients with Diabetes Mellitus
Background: Dyspnoea on exertion in a diabetic patient readily arouses the suspicion of cardiovascular disease and/or physical de conditioning. Diabetic lung involvement did not gain wide recognition until recently. Henc...