Aktualne spojrzenie na marsz alergiczny i rolę atopowego zapalenia skóry w jego rozwoju
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2018, Vol 72, Issue
Abstract
An increasing morbidity of atopic diseases (atopic dermatitis, food allergy, asthma and allergic rhinitis) documented in large cohort epidemiological studies is at least partially determined by high hygienic standards of living. Over the last 40 years, the accepted concept of pathogenesis of atopic diseases, the so-called atopic march, was proposed by Fouchard in 1973. It referred to the natural history of atopy manifestation, with a typical sequence of symptoms presented as atopic dermatitis in early childhood for subsequent development of allergic respiratory symptoms in late childhood and adolescence. New data suggests that the leading role of atopic dermatitis in atopic march might be less pronounced than previously expected, indicating coexistence rather than succession of atopic symptoms. The objective of this paper is to present the currently discussed concepts of atopic dermatitis – its pathogenesis, etiology, course and role in the development of other allergic diseases. More widely, we will present: 1. The genetic factors involved in skin barrier disruption with the leading role of loss-of-function gene for filaggrin mutation, 2. Genetic defects and epigenetic regulation of the immune system 3. Epidermal changes with physical barrier dysfunction as well as 4. Skin microbiome disturbances with Staphylococcus aureus colonization leading to abnormalities of the epidermal protective barrier.
Authors and Affiliations
Karolina Gwoździewicz, Ewa Cichocka-Jarosz
Keywords
Related Articles
- EP ID EP262718
- DOI 10.5604/01.3001.0010.8706
- Views 152
- Downloads 0
Komórki tuczne w infekcjach wirusowych[u][/u]
Wiele przesłanek wskazuje, że komórki tuczne współuczestniczą w mechanizmach obronnych skierowanych przeciwko wirusom oraz biorą udział w patomechanizmie chorób wirusowych. Komórki tuczne są bardzo liczne w miejscach st...
Potencjalne czynniki patogenne w stwardnieniu rozsianym (SM)
Stwardnienie rozsiane jest chorobą neuroimmunologiczną, w której jeszcze nie udało się zidentyfikować czynnika etiologicznego. Etiologia SM jest złożona i może się wiązać z wieloma różnymi czynnikami działającymi jednoc...
Investigations of seborrheic dermatitis. Part I. The role of selected cytokines in the pathogenesis of seborrheic dermatitis
Introduction: The etiology of seborrheic dermatitis is not fully understood. It has been observed that a number of anascogenic yeasts of Malassezia spp. is related to the intensity of the symptoms. The aim of the study i...
The role of protein AS160/TBC1D4 in the transport of glucose into skeletal muscles
Skeletal muscle plays an essential role in the regulation of whole-body glucose homeostasis. Glucose is transported into the muscle cells via protein-mediated transport that requires sarcolemmal glucose transporters (G...
Czy geny KIR są związane z klinicznymi parametrami w przebiegu choroby przyzębia?