ΑLFA GLUCOSIDASE INHIBITORY ACTIVITY OF KAYU TUAH (ANTIDESMA CELEBICUM MIQ.)
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 11
Abstract
Ethanolic extracts of kayutuah (Antidesma celebicum Miq.) leaves and stem bark were evaluated for their antidiabetic activity by inhibition of α-Glucosidase. Each ethanolic extract was fractionated using n-hexane, ethyl acetate, and methanol. The result showed that the ethyl acetate fraction of kayutuahstem bark had the highest α- Glucosidase inhibitory activity with IC50 value 8.06 µg/mL. The ethyl acetate fractionwas conducted by chromatographic column using various organic solvent and obtained 10 sub fractions (A-J). The subfraction2.E [n-hexane:ethyl acetate (20:80)] had the highest activity as anti diabetic with IC50 value 5.60 µg/mL and itscontain of tannins, saponins, terpens, and glycosides.
Authors and Affiliations
Elya Berna , Katrin Basah , Fajar Novi , Marista GM, Anindita RA
Keywords
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- EP ID EP93758
- DOI 10.7897/2230-8407.041107
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