Allergic bronchopulmonary aspergillosis: XXI century. A modern view on the problem
Journal Title: Астма и Аллергия - Year 2018, Vol 1, Issue 4
Abstract
Aspergillus organisms are widely ubiquitous in the environment and can cause a great number of pathological syndromes mainly in immunocom promised patients . However , aspergillosis lesion may occur not only in patients with immunodeficiency . Allergic bronchopulmonary aspergillosis is a noninvasive form of Aspergillus lung disease , occurring in nonimmunocompromised patients and manifesting with poorly controlled severe asthma . The pathogenesis of this disease is not understood completely . But there are a lot of investigations those can shed the light on some mechanisms of disease development . The diagnosis is based on results of different tests such as aspergillus skin test , total and specific serum IgE levels , specific se rum IgG levels , high resolution computed tomography , investigation of sputum culture etc . Based on typical symptoms and data of laboratory and instrumental methods , diagnostic criteria were formulated . Purposes of treatment includes asthma control , prevention and treatment of exacerbations , prevention of bronchiectasis development . The basic principles of treatment are immunosuppression and eradication of the pathogen from the or ganism . Oral and inhaled corticosteroids , antifungal drugs and anti IgE monoclonal antibodies are used . But there are not official recommendations about dosage , drug regimen and duration of treatment . Therefore , treatment options described in different works are based on individual experience of patient management . The development of molecular allergology opens new perspectives for diagnosis and treatment of this disease . New antigenic components of A . fumigatus are released and new vaccine for antigen specific immunotherapy are developed . But efficiency and expediency of this diagnostic and treatment method need to be investigated
Authors and Affiliations
T. O. Pertseva, K. Yu. Gashynova, D. O. Sokur
Keywords
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- EP ID EP462785
- DOI 10.31655/2307-3373-2018-4-29-36
- Views 157
- Downloads 0
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