Allergic reacton to long – term Benzathine penicillin injecton for secondary preventon of acute rheumatc fever and recommendatons for skin testng
Journal Title: Nepalese Heart Journal - Year 2011, Vol 8, Issue 1
Abstract
Background Rheumatc Fever (RF) causes 25-40% of all cardio vascular disease in developing countries. Long term benzathine penicillin injecton is being used for secondary prophylaxis of RF / RHD. Although allergic reacton to penicillin is rare skin testng is performed routnely before each and every penicillin injecton delivery in most of the hospitals in Nepal. Objectves Objectves of this study was to evaluate safety of long term benzathine penicillin injecton and establish recommendatons for penicillin skin testng. Methods Data from the registers of Natonal RF/RHD preventon and control programme from 32 hospitals of Nepal were collected and analyzed in a retrospectve study. Results 65 patents (1.4%) among 77300 injectons of benzathine penicillin given to 4712 patents, had allergic reactons. 5 had anaphylaxis, an incidence of 0.1% (0.7/10000 injectons), 60 had minor allergy, an incidence of 1.3%. Conclusions Life-threatening allergic reactons are very rare in patents on long-term intramuscular benzathine penicillin for secondary preventon of RF. With these rare complicatons, regular skin test before each and every benzathine penicillin injecton delivery has no signifcant role. Nevertheless Skin testng is recommended before 1st injecton and patents having different batch number and or brand name.
Authors and Affiliations
Regmi P. R| Natonal Academy of Medical Sciences, Bir hospital Medicare Natonal Hospital and research centre, Upadhyaya AB| Natonal Academy of Medical Sciences, Bir hospital Medicare Natonal Hospital and research centre
Keywords
Related Articles
- EP ID EP15696
- DOI http://dx.doi.org/10.3126/njh.v8i1.8331
- Views 391
- Downloads 21
Effect of Oral Clonidine on Hemodynamic Response During Surgery
Clonidine is an alpha 2-adrenoceptor agonist. It has recently, however, found a new and possibly signifcant role in anaesthesia and the treatment of pain. Diazepam has been used as a drug for premedication for years bu...
Observational Study of Pulmonary Embolism Patients in Shahid Gangalal National Heart Centre
Pulmonary thromboembolism (PE) is a relatively common cardiovascular emergency, with a signifcant mortality and morbidity often precipitated by deep venous thrombosis (DVT).It is considered as the third most common cardi...
ALADPA : Snake in the Heart
Anomalous origin of left coronary artery from pulmonary artery may or may not be associated with structural heart disease. Most of the patients with such coronary anomaly will succumb unless diagnosed and treated early....
Obstetric outcome in patients with rheumatic heart disease: experience of a tertiary hospital
Background and Aims: Pregnancy in patients with rheumatic heart disease has always been challenging. Haemodynamic changes in pregnancy with diseased heart may cause adverse maternal and fetal outcome. Methods: A prospe...
Pattern of Heart Valve Involvement in Rheumatic Heart Disease
Rheumatic heart disease is the most important consequence of acute rheumatic fever. Both are common cardiovascular problems in Nepal. Echocardiographic detection of rheumatic heart disease is important to establish the...