Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats
Journal Title: Journal of Pharmacy & Pharmacognosy Research - Year 2014, Vol 2, Issue 2
Abstract
Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms. Aims: To study the potential protection of an aqueous extract of Allium sativum against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats. Methods: Twenty four hours after treatment, biomarkers such as proteinuria, creatinine clearance, malondialdehyde production, specific enzyme activity of gamma glutamyl transpeptidase and alanine aminopeptidase, and renal clearance of para-aminohippuric acid and inulin were measured. Results: The K2Cr2O7 caused significant renal dysfunction, but A. sativum extract prevented this condition by improving all measured biomarkers. Conclusions: A single injection of K2Cr2O7 induced nephrotoxicity in rats, but the supply of an Allium sativum aqueous extract prevented the disorders caused by this metal.
Desmodium gangeticum root extract attenuates isoproterenol-induced cardiac hypertrophic growth in rats
Context: Desmodium gangeticum (L) DC (Fabaceae; DG), a medicinal plant that grows in tropical habitats, is widely used to treat various ailments including digestive and inflammatory disorders. Aims: To investigate the po...
Effects of Sonchus asper and apigenin-7-glucoside on nociceptive behaviors in mice
Context: Sonchus asper is an important herbal medicine that traditionally used to treatment of digestive system infections and heart disease. Aims: To evaluate of anti-inflammatory and antinociceptive effects of Sonchus...
Nephroprotective and hepatoprotective effects of Tribulus terrestris L. growing in Saudi Arabia
Context: Tribulus terrestris (Zygophyllaceae) is a popular leafy prostrate branching herb used in folk medicine as a diuretic and urinary antiseptic. Aims: To evaluate the hepatoprotective and nephroprotective activitie...
Patterns of self-medication in customers of a community pharmacy in the Antofagasta city
Context: Self-medication is the use of unprescribed drugs; this means that people obtain drugs on their own initiative and without the assistance of health professionals. This is an increasingly common practice among the...
Anti-adhesion and antibiotic modulatory evaluation of grapefruit (Citrus paradisi) juice and seed extract on bacteria isolated from urine and catheter
Context: The in vivo use of grapefruit seed in the treatment of urinary tract infections (UTIs) has been reported but the mechanism of action is yet to be explained. Aims: Evaluate the anti-adhesion and antibiotic modul...