Allogeneic Stem Cell Transplantation to cure Acute Myeloid Leukemia in elderly patients

Journal Title: Journal of Advances in Internal Medicine - Year 2012, Vol 1, Issue 1

Abstract

Outcomes for elderly patients with acute myeloid leukemia (AML) remain poor with standard therapies. Historically this age group has been excluded from treatment with allogeneic stem cell transplantation (allo-SCT) due to worries of excessive treatment related morbidity and mortality. However, transplantation outcomes have dramatically improved in the last decade due to the widespread use of less ablative conditioning regimens, improved supportive care, and improved patient selection based on prognostic tools such as the hematopoietic cell transplant specific comorbidity index. These have all led to an increasing acceptance of allo-SCT as a potential treatment modality in elderly patients with AML. This review addresses current strategies for patient selection and efficacy data for allo-SCT in elderly patients with AML.

Authors and Affiliations

Pritesh Patel*| Section of Hematology/Oncology and University of Illinois Cancer Center, University of Illinois Hospital and Health Science System, Chicago, USA, Santosh Saraf| Section of Hematology/Oncology and University of Illinois Cancer Center, University of Illinois Hospital and Health Science System, Chicago, USA, Damiano Rondelli| Section of Hematology/Oncology and University of Illinois Cancer Center, University of Illinois Hospital and Health Science System, Chicago, USA

Keywords

Related Articles

Comparision of Various Vasodilators Regimen During Radial Corornary Angiogram: A Prospective Randomised Trial

Background and Aims: Coronary intervention through radial artery is a preferred over femoral route. Different vasodilators are used to prevent radial artery spasm. Till date there is no study to compare the effects of va...

Hair Dye poisoning – A rare case Report

Hair dye poisoning is not uncommon but an emerging entity in India with increased morbidity and mortality. The main component of hair dye poisoning is paraphenylenediamine(PPD), which is highly toxic thus making it life...

Skin Lesions and Lower Extremity Edema in a newly diagnosed HIV patient

The differential diagnosis of skin lesions in human immunodeficiency virus patients is diverse and includes both infectious and non infectious causes. In this case presentation, a 37 year old male newly diagnosed with HI...

IN VITRO SELECTION FOR SALT TOLERANCE IN LENTIL (LENS CULINARIS MEDIK)

While plant breeding methods have been diverted toward improve of real crop yield in drought and salinity conditions, the achievement of plant cell culture and regeneration of plants from mutant cells is increasingly i...

Gastrointestinal Mantle Cell Lymphoma: incidental finding on routine CT scan following pneumothorax

Gastric mantle cell lymphoma is a rare form of gastrointestinal tumor and represents 2.5–7% of all non-Hodgkin’s lymphomas. A 69-year-old maleadmitted with spontaneous pneumothorax was found to have a gastric masson CT...

Download PDF file
  • EP ID EP4754
  • DOI http://dx.doi.org/10.3126/jaim.v1i1.5840
  • Views 348
  • Downloads 24

How To Cite

Pritesh Patel*, Santosh Saraf, Damiano Rondelli (2012). Allogeneic Stem Cell Transplantation to cure Acute Myeloid Leukemia in elderly patients. Journal of Advances in Internal Medicine, 1(1), 43-49. https://europub.co.uk/articles/-A-4754