Allopurinol Lowers Blood Pressure, Uric Acid and Endothelin-1 in Hypertensive Patients with Hyperuricemia at Mohammad Hoesin Hosiptal, Palembang, Indonesia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Scientific reports suggesting a link between hypertension and hyperuricemia are considerable. However, little is known whether drugs that had proven to be effective in reducing uric acid will also efficative to overcome hypertension? To answer the question a clinical trial using allopurinol has been employed on the hypertensive patients with asymptomatic hyperuricemia. A total of 40 patients that fulfilled inclusion criteria, were separated by double-blind randomization into two groups, the allopurinol and placebo. The allopurinoltreated patients included 9 males and 11 females, while placebo consist of 10 males and 10 females. To each patient of both groups were given one capsule containing 100 mg of allopurinol for allopurinol group or nonactive substance for placebo group for a month. Before and after trials the systolic as well as diastolic pressure, endothelin (ET)-1 uricacid levels of the subjects were assessed. The results showed patients treated with allopurinol siginicantly lower in systolic pressure (P=0.013), diastolic pressure (P=0.012), uric acid levels (P<0.001) and ET-1 levels (P=0,009). Thus, it can suggested that allopurinol is potent to be use as a remedy to overcome hypertension with hyperuricemia
Authors and Affiliations
Achmad Taruna, Ellyza Nasrul, Eryati Darwin, Eva Decroli
Keywords
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- EP ID EP251462
- DOI 10.9790/0853-1612094246
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